Distribution and antimicrobial activity of ciprofloxacin in human soft tissues

被引：63

作者：

Brunner, M

Hollenstein, U

Delacher, S

Jäger, D

Schmid, R

Lackner, E

Georgopoulos, A

Eichler, HG

Müller, M

机构：

[1] Univ Vienna, Sch Med, Dept Clin Pharmacol, Vienna, Austria

[2] Univ Vienna, Sch Med, Dept Internal Med 1, Div Infect Dis & Chemotherapy, Vienna, Austria

[3] Univ Vienna, Sch Med, Dept Clin & Lab Invest, Vienna, Austria

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 05期

关键词：

D O I：

10.1128/AAC.43.5.1307

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Interstitial ciprofloxacin concentrations in soft tissues were measured by microdialysis following intravenous administration of 200 mg to each of eight healthy volunteers. Interstitial ciprofloxacin concentrations were significantly lower than corresponding total serum drug concentrations; the interstitium-to-serum concentration ratios ranged from 0.55 to 0.73. An in vitro simulation based on interstitial pharmacokinetics showed a substantially lower antimicrobial activity than did the simulation based on serum pharmacokinetics. Thus, ciprofloxacin concentrations at the site of effect may be subinhibitory although effective concentrations are attained in serum.

引用

页码：1307 / 1309

页数：3

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