Tumor-Associated Macrophage Status in Cancer Treatment

被引：152

作者：

Malfitano, Anna Maria ^{[1
]}

Pisanti, Simona ^{[2
]}

Napolitano, Fabiana ^{[1
]}

Di Somma, Sarah ^{[1
]}

Martinelli, Rosanna ^{[2
]}

Portella, Giuseppe ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Translat Med Sci, I-80131 Naples, Italy

[2] Univ Salerno, Scuola Med Salernitana, Dept Med Surg & Dent, Via Salvador Allende, I-84081 Salerno, Italy

来源：

CANCERS | 2020年 / 12卷 / 07期

关键词：

tumor-associated macrophages; chemotherapy; radiotherapy; immune-checkpoint blocking therapy; oncolytic virus; virotherapy; REGULATORY T-CELLS; ACTIVATED MACROPHAGES; IONIZING-RADIATION; PERITONEAL-MACROPHAGES; ONCOLYTIC VIROTHERAPY; PANCREATIC-CANCER; TNF-ALPHA; METASTASES; BREAST; INHIBITION;

D O I：

10.3390/cancers12071987

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Tumor-associated macrophages (TAMs) represent the most abundant innate immune cells in tumors. TAMs, exhibiting anti-inflammatory phenotype, are key players in cancer progression, metastasis and resistance to therapy. A high TAM infiltration is generally associated with poor prognosis, but macrophages are highly plastic cells that can adopt either proinflammatory/antitumor or anti-inflammatory/protumor features in response to tumor microenvironment stimuli. In the context of cancer therapy, many anticancer therapeutics, apart from their direct effect on tumor cells, display different effects on TAM activation status and density. In this review, we aim to evaluate the indirect effects of anticancer therapies in the modulation of TAM phenotypes and pro/antitumor activity.

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页数：25

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