Hemispheric differences on auditory evoked response suppression in schizophrenia

被引:16
作者
Blumenfeld, LD [1 ]
Clementz, BA [1 ]
机构
[1] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA
关键词
auditory evoked response suppression; M100; magnetoencephalography; schizophrenia;
D O I
10.1097/00001756-199908200-00027
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
USING binaural stimuli, schizophrenia subjects have worse auditory evoked response (AER) suppression than normals in a paired-click paradigm. In this study we investigated hemispheric differences in AER suppression between groups using monaural and binaural stimulus presentation. Auditory evoked responses from 12 schizophrenia and 12 normal subjects were recorded with a 148-channel whole-head biomagnetometer. One hundred and twenty pairs of clicks were presented in three counterbalanced blocks (left, right, binaural). With monaural stimuli, patients had worse M100 suppression than normals in ipsilateral (effect size -2.13) but not in contralateral hemisphere (effect size -0.43). The groups did not differ on gamma band response suppression. Overall, the best group separations were obtained with binaural stimulus presentation on M100 suppression (effect size -4.14). (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:2587 / 2591
页数:5
相关论文
共 25 条
[1]  
[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th
[2]  
Barta PE, 1997, AM J PSYCHIAT, V154, P661
[3]  
BASAR E, 1987, INT J NEUROSCI, V33, P103
[4]   The gamma band response may account for poor P50 suppression in schizophrenia [J].
Clementz, BA ;
Blumenfeld, LD ;
Cobb, S .
NEUROREPORT, 1997, 8 (18) :3889-3893
[5]   Multiple site evaluation of P50 suppression among schizophrenia and normal comparison subjects [J].
Clementz, BA ;
Geyer, MA ;
Braff, DL .
SCHIZOPHRENIA RESEARCH, 1998, 30 (01) :71-80
[6]   P50 suppression among schizophrenia and normal comparison subjects: A methodological analysis [J].
Clementz, BA ;
Geyer, MA ;
Braff, DL .
BIOLOGICAL PSYCHIATRY, 1997, 41 (10) :1035-1044
[7]   LOSS OF SYLVIAN FISSURE ASYMMETRY IN SCHIZOPHRENIA - A QUANTITATIVE POST-MORTEM STUDY [J].
FALKAI, P ;
BOGERTS, B ;
GREVE, B ;
PFEIFFER, U ;
MACHUS, B ;
FOLSCHREETZ, B ;
MAJTENYI, C ;
OVARY, I .
SCHIZOPHRENIA RESEARCH, 1992, 7 (01) :23-32
[8]  
FREEDMAN R, 1983, BIOL PSYCHIAT, V18, P537
[9]   HUMAN BRAIN - LEFT-RIGHT ASYMMETRIES IN TEMPORAL SPEECH REGION [J].
GESCHWIND, N ;
LEVITSKY, W .
SCIENCE, 1968, 161 (3837) :186-+
[10]   Real-time imaging of neural activity during binaural interaction in the guinea pig auditory cortex [J].
Hosokawa, Y ;
Horikawa, J ;
Nasu, M ;
Taniguchi, I .
JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 1997, 181 (06) :607-614