Risk factors contributing to hepatic artery thrombosis following living-donor liver transplantation

被引:43
作者
Ikegami, T
Hashikura, Y
Nakazawa, Y
Urata, K
Mita, A
Ohno, Y
Terada, M
Miyagawa, S
Kushima, H
Kondoh, S
机构
[1] Shinshu Univ, Sch Med, Dept Surg, Matsumoto, Nagano 3908621, Japan
[2] Shinshu Univ, Sch Med, Dept Plast Surg, Matsumoto, Nagano 3908621, Japan
来源
JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY | 2006年 / 13卷 / 02期
关键词
sex; metabolic liver disease; vascular reconstruction; anticoagulation;
D O I
10.1007/s00534-005-1015-y
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Purpose. This study was carried out to investigate the risk factors contributing to hepatic artery thrombosis in living-donor liver transplantation. Methods. Two hundred and twenty-two recipients (113 adults and 109 children) of living-donor liver transplantation were the subjects of this study. The diagnosis of hepatic artery thrombosis was made by color-Doppler ultrasonography and/or hepatic angiography. Parameters for this study were: (1) donor sex, age, and body weight; (2) recipient sex, age, body weight, liver disease, preoperative prothrombin time, and type of arterial reconstruction; and (3) previous liver transplantation. Results. Hepatic artery thrombosis occurred in 12 patients (5.4%) at 3 to 15 days posttransplant. Recipient female sex and metabolic disorder as the original disease were found to be significantly associated with hepatic artery thrombosis. The 5-year patient survival rate in recipients with hepatic artery thrombosis (58.3%) was significantly lower than that in recipients without this complication (84.4%). Conclusions. Female sex and metabolic disease may be factors contributing to hepatic artery thrombosis after living-donor liver transplantation. More intensive anticoagulation therapy for this patient population might decrease the incidence of hepatic artery thrombosis and, thus, posttransplant recipient mortality.
引用
收藏
页码:105 / 109
页数:5
相关论文
共 23 条
  • [1] BUCKELS JAC, 1989, TRANSPLANT P, V21, P2460
  • [2] Drazan K, 1996, AM SURGEON, V62, P237
  • [3] FIGUERAS J, 1995, TRANSPLANTATION, V59, P1356
  • [4] Late hepatic artery thrombosis after orthotopic liver transplantation
    Gunsar, F
    Rolando, N
    Pastacaldi, S
    Patch, D
    Raimondo, ML
    Davidson, B
    Rolles, K
    Burroughs, AK
    [J]. LIVER TRANSPLANTATION, 2003, 9 (06) : 605 - 611
  • [5] Should all hepatic arterial branches be reconstructed in living-related liver transplantation?
    Ikegami, T
    Kawasaki, S
    Matsunami, F
    Hashikura, Y
    Nakazawa, Y
    Miyagawa, S
    Furuta, S
    Iwanaka, T
    Makuuchi, M
    [J]. SURGERY, 1996, 119 (04) : 431 - 436
  • [6] Long-term survival after liver transplantation in 4,000 consecutive patients at a single center
    Jain, A
    Reyes, J
    Kashyap, R
    Dodson, F
    Demetris, AJ
    Ruppert, K
    Abu-Elmagd, K
    Marsh, W
    Madariaga, J
    Mazariegos, G
    Geller, D
    Bonham, CA
    Gayowski, T
    Cacciarelli, T
    Fontes, P
    Starzl, TE
    Fung, JJ
    [J]. ANNALS OF SURGERY, 2000, 232 (04) : 490 - 498
  • [7] KAWASAKI S, 1993, HEPATOLOGY, V18, P1115
  • [8] KLINTMALM GB, 1988, TRANSPLANT P, V20, P610
  • [9] HEPATIC ALLOGRAFT RESCUE FOLLOWING ARTERIAL THROMBOSIS - ROLE OF URGENT REVASCULARIZATION
    LANGNAS, AN
    MARUJO, W
    STRATTA, RJ
    WOOD, RP
    LI, SJ
    SHAW, BW
    [J]. TRANSPLANTATION, 1991, 51 (01) : 86 - 90
  • [10] VASCULAR COMPLICATIONS AFTER ORTHOTOPIC LIVER-TRANSPLANTATION
    LANGNAS, AN
    MARUJO, W
    STRATTA, RJ
    WOOD, RP
    SHAW, BW
    [J]. AMERICAN JOURNAL OF SURGERY, 1991, 161 (01) : 76 - 83