Background/Purpose. This study was carried out to investigate the risk factors contributing to hepatic artery thrombosis in living-donor liver transplantation. Methods. Two hundred and twenty-two recipients (113 adults and 109 children) of living-donor liver transplantation were the subjects of this study. The diagnosis of hepatic artery thrombosis was made by color-Doppler ultrasonography and/or hepatic angiography. Parameters for this study were: (1) donor sex, age, and body weight; (2) recipient sex, age, body weight, liver disease, preoperative prothrombin time, and type of arterial reconstruction; and (3) previous liver transplantation. Results. Hepatic artery thrombosis occurred in 12 patients (5.4%) at 3 to 15 days posttransplant. Recipient female sex and metabolic disorder as the original disease were found to be significantly associated with hepatic artery thrombosis. The 5-year patient survival rate in recipients with hepatic artery thrombosis (58.3%) was significantly lower than that in recipients without this complication (84.4%). Conclusions. Female sex and metabolic disease may be factors contributing to hepatic artery thrombosis after living-donor liver transplantation. More intensive anticoagulation therapy for this patient population might decrease the incidence of hepatic artery thrombosis and, thus, posttransplant recipient mortality.
机构:
Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Gunsar, F
Rolando, N
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Rolando, N
Pastacaldi, S
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Pastacaldi, S
Patch, D
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Patch, D
Raimondo, ML
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Raimondo, ML
Davidson, B
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Davidson, B
Rolles, K
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Rolles, K
Burroughs, AK
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Gunsar, F
Rolando, N
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Rolando, N
Pastacaldi, S
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Pastacaldi, S
Patch, D
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Patch, D
Raimondo, ML
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Raimondo, ML
Davidson, B
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Davidson, B
Rolles, K
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England
Rolles, K
Burroughs, AK
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Royal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, EnglandRoyal Free Hosp, Dept Med, Liver Transplantat & Hepatobiliary Unit, London NW3 2QG, England