Chemoenzymatic enantioselective synthesis of (1S,5R)-(-)-frontalin

被引：15

作者：

Chênevert, R ^{[1
]}

Caron, D ^{[1
]}

机构：

[1] Univ Laval, Fac Sci & Genie, Dept Chim, Quebec City, PQ G1K 7P4, Canada

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0957-4166(02)00085-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The pheromone (1S,5R)-(-)-frontalin was synthesized in 90% e.e. via a chemoenzymatic route. The key step, as the stereoselective acylation (desymmetrization) of 2-(4,5-d hydroxy-4-hydroxymethylpentyl)-2-methyl-1,3-dioxolane with vinyl acetate in organic media in the presence of Pseudomonas sp. lipase. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：339 / 342

页数：4

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