The transport of manganese across the blood-brain barrier

被引：33

作者：

Aschner, M ^{[1
]}

机构：

[1] Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA

来源：

NEUROTOXICOLOGY | 2006年 / 27卷 / 03期

关键词：

manganese; transport; transferrin; neurotoxicity; divalent metal transporter-1 (DMT-1); blood-brain barrier;

D O I：

10.1016/j.neuro.2005.09.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mammalian central nervous system (CNS) possesses a unique and specialized capillary adaptation, referred to as the blood-brain barrier (BBB). The BBB maintains an optimal neuronal microenvironment, regulating blood-tissue exchange of macromolecules and nutrients. The BBB is characterized by individual endothelial cells that are continuously linked by tight junctions, inhibiting the diffusion of macromolecules and solutes between adjacent endothelial cells. This review will focus on pertinent issues to BBB maintenance. and survey recent dogmas on the transport mechanisms for the essential metal, manganese, across this barrier. Specifically, putative carriers for manganese into and out of the brain will be discussed. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：311 / 314

页数：4

共 28 条

[1]

AISEN P, 1969, J BIOL CHEM, V244, P4628

[2] MANGANESE POISONING AND THE ATTACK OF TRIVALENT MANGANESE UPON CATECHOLAMINES [J].

ARCHIBALD, FS ;

TYREE, C .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1987, 256 (02) :638-650

[3] MANGANESE (MN) TRANSPORT ACROSS THE RAT-BLOOD BRAIN BARRIER - SATURABLE AND TRANSFERRIN-DEPENDENT TRANSPORT MECHANISMS [J].

ASCHNER, M ;

GANNON, M .

BRAIN RESEARCH BULLETIN, 1994, 33 (03) :345-349

[4] Differential cytotoxicity of Mn(II) and Mn(III): Special reference mitochondrial [Fe-S] containing enzymes [J].

Chen, JY ;

Tsao, GC ;

Zhao, QQ ;

Zheng, W .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2001, 175 (02) :160-168

[5] Manganese metabolism is impaired in the Belgrade laboratory rat [J].

Chua, ACG ;

Morgan, EH .

JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY, 1997, 167 (05) :361-369

[6] CHRONIC MANGANESE POISONING - CLEARANCE OF TISSUE MANGANESE CONCENTRATIONS WITH PERSISTENCE OF NEUROLOGICAL PICTURE [J].

COTZIAS, GC ;

HORIUCHI, K ;

FUENZALIDA, S ;

MENA, I .

NEUROLOGY, 1968, 18 (04) :376-+

[7] Manganese distribution across the blood-brain barrier III - The divalent metal transporter-1 is not the major mechanism mediating brain manganese uptake [J].

Crossgrove, JS ;

Yokel, RA .

NEUROTOXICOLOGY, 2004, 25 (03) :451-460

[8] IDENTIFICATION OF TRANSFERRIN AS THE MAJOR PLASMA CARRIER PROTEIN FOR MANGANESE INTRODUCED ORALLY OR INTRAVENOUSLY OR AFTER INVITRO ADDITION IN THE RAT [J].

DAVIDSSON, L ;

LONNERDAL, B ;

SANDSTROM, B ;

KUNZ, C ;

KEEN, CL .

JOURNAL OF NUTRITION, 1989, 119 (10) :1461-1464

[9]

Davson H, 1996, Physiology of the CSF and blood-brain barriers

[10] Distribution of injected iron 59 and manganese 54 in hypotransferrinemic mice [J].

Dickinson, TK ;

Devenyi, AG ;

Connor, JR .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1996, 128 (03) :270-278

← 1 2 3 →