Surrogate tissue telomere length and cancer risk: Shorter or Longer?

被引：114

作者：

Hou, Lifang ^{[1
,2
]}

Zhang, Xiao ^{[1
]}

Gawron, Andrew J. ^{[3
]}

Liu, Jie ^{[4
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Div Gastroenterol & Hepatol, Dept Med, Chicago, IL 60611 USA

[4] Fudan Univ, Huashan Hosp, Dept Digest Dis, Shanghai 200040, Peoples R China

来源：

CANCER LETTERS | 2012年 / 319卷 / 02期

关键词：

Telomere length; Surrogate tissue DNA; Cancer risk; INCIDENT COLORECTAL-CARCINOMA; BREAST-CANCER; CIGARETTE-SMOKING; PREDISPOSITION FACTOR; GENETIC-VARIATION; OXIDATIVE DAMAGE; QUANTITATIVE PCR; BLADDER-CANCER; PULSE PRESSURE; BLOOD-CELLS;

D O I：

10.1016/j.canlet.2012.01.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Telomeres play a critical role in chromosome stability. Telomere length (TL) shortening is a risk factor for cancers. Measuring TL in surrogate tissues that can be easily collected may provide a potential tool for early detection of cancers. A number of studies on surrogate tissue TL and cancer risks have been conducted and results are inconsistent, including positive, negative, or null associations. In this article, we reviewed the published data on surrogate tissue TL in relation to cancer risks, discussed the possible reasons for the differences in the results and future directions and challenges for this line of research. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：130 / 135

页数：6

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