Lymphocyte proliferative responses of goats vaccinated with Brucella melitensis 16M or a Delta purE201 strain

被引：6

作者：

Olsen, SC

Cheville, NF

Stevens, MG

Houng, HH

Drazek, ES

Hadfield, TL

Warren, RL

Hoover, DL

机构：

[1] IOWA STATE UNIV,DEPT PATHOL,AMES,IA 50011

[2] WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307

[3] WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307

[4] ARMED FORCES INST PATHOL,DEPT INFECT & PARASIT DIS,WASHINGTON,DC 20306

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 07期

关键词：

D O I：

10.1128/IAI.65.7.2987-2991.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The response to a Brucella melitensis purEK deletion mutant, Delta purE201 (referred to as strain 201), was compared with the response to its parental strain, 16M, in juvenile goats. Proliferative responses to gamma-irradiated bacteria were detected earlier in strain 201-infected goats. Lymphocytes from strain 16M- or 201-infected goats proliferated in response to one-dimensional polyacrylamide gel electrophoresis-separated proteins of similar mass isolated from strain 16M or Brucella abortus RB51. Data from this study suggest that some antigens stimulating cell-mediated responses are conserved among Brucella species, as 201- and 16M-infected goats recognized similar proteins expressed by RB51 and 16M.

引用

页码：2987 / 2991

页数：5

共 12 条

[1]

Alton GG, 1990, ANIMAL BRUCELLOSIS, P384

[2]

CHEVILLE NF, 1993, AM J VET RES, V54, P1591

[3] Bacterial persistence and immunity in goats vaccinated with a purE deletion mutant or the parental 16M strain of Brucella melitensis [J].