Growth hormone receptor; mechanism of action

被引：84

作者：

Brooks, Andrew J. ^{[1
]}

Wooh, Jong Wei

Tunny, Kathryn A.

Waters, Michael J.

机构：

[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2008年 / 40卷 / 10期

关键词：

growth hormone receptor; nuclear localisation; Janus kinase; Src kinase; cancer;

D O I：

10.1016/j.biocel.2007.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The growth hormone receptor has been an archetype for ligand-induced receptor dimerisation in cytokine receptor signalling. However, we now know that it exists as a constitutive dimer and is activated by a reorganisation of receptor subunits as a result of asymmetric placement of two receptor binding sites on the hormone monomer. This review highlights several topics including: current models of receptor activation; recent advances in the understanding of GH signalling demonstrating that ligand-induced signalling activates Src/ERK pathway in parallel to the classical JAK2-STAT5 signalling; and the nuclear localised growth hormone receptor correlates with high proliferation status and carcinogenesis. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1984 / 1989

页数：6

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