Growth hormone receptor; mechanism of action

被引：85

作者：

Brooks, Andrew J. ^{[1
]}

Wooh, Jong Wei

Tunny, Kathryn A.

Waters, Michael J.

机构：

[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2008年 / 40卷 / 10期

关键词：

growth hormone receptor; nuclear localisation; Janus kinase; Src kinase; cancer;

D O I：

10.1016/j.biocel.2007.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The growth hormone receptor has been an archetype for ligand-induced receptor dimerisation in cytokine receptor signalling. However, we now know that it exists as a constitutive dimer and is activated by a reorganisation of receptor subunits as a result of asymmetric placement of two receptor binding sites on the hormone monomer. This review highlights several topics including: current models of receptor activation; recent advances in the understanding of GH signalling demonstrating that ligand-induced signalling activates Src/ERK pathway in parallel to the classical JAK2-STAT5 signalling; and the nuclear localised growth hormone receptor correlates with high proliferation status and carcinogenesis. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1984 / 1989

页数：6

共 27 条

[1] IFN-γ and its receptor subunit IFNGR1 are recruited to the IFN-γ-activated sequence element at the promoter-site of IFN-γ-activated genes:: Evidence of transactivational activity in IFNGR1 [J].

Ahmed, CMI ;

Johnson, HM .

JOURNAL OF IMMUNOLOGY, 2006, 177 (01) :315-321

[2] Involvement of the Src kinase Lyn in phospholipase C-γ2 phosphorylation and phosphatidylinositol 3-kinase activation in Epo signalling [J].

Boudot, C ;

Dassé, E ;

Lambert, E ;

Kadri, Z ;

Mayeux, P ;

Chrétien, S ;

Haye, B ;

Billat, C ;

Petitfrère, E .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 300 (02) :437-442

[3] Model for growth hormone receptor activation based on subunit rotation within a receptor dimer [J].

Brown, RJ ;

Adams, JJ ;

Pelekanos, RA ;

Wan, Y ;

McKinstry, WJ ;

Palethorpe, K ;

Seeber, RM ;

Monks, TA ;

Eidne, KA ;

Parker, MW ;

Waters, MJ .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2005, 12 (09) :814-821

[4]

CONWAYCAMPBELL BL, 2007, P NATT ACAD IN PRESS

[5] Growth hormone receptor is a target for presenilin-dependent γ-secretase cleavage [J].

Cowan, JW ;

Wang, XD ;

Guan, R ;

He, K ;

Jiang, J ;

Baumann, G ;

Black, RA ;

Wolfe, MS ;

Frank, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (19) :19331-19342

[6] Growth hormone deficiency and related disorders: insights into causation, diagnosis, and treatment [J].

Dattani, M ;

Preece, M .

LANCET, 2004, 363 (9425) :1977-1987

[7] Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2 [J].

Funakoshi-Tago, Megumi ;

Pelletier, Stephane ;

Matsuda, Tadashi ;

Parganas, Evan ;

Ihle, James N. .

EMBO JOURNAL, 2006, 25 (20) :4763-4772

[8] Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis [J].

Gent, J ;

van Kerkhof, P ;

Roza, M ;

Bu, GJ ;

Strous, GJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :9858-9863

[9] Endosomal transport of ErbB-2: Mechanism for nuclear entry of the cell surface receptor [J].

Giri, DK ;

Ali-Seyed, M ;

Li, LY ;

Lee, DF ;

Ling, P ;

Bartholomeusz, G ;

Wang, SC ;

Hung, MC .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (24) :11005-11018

[10] Jak2: normal function and role in hematopoietic disorders [J].

Ihle, James N. ;

Gilliland, D. Gary .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2007, 17 (01) :8-14

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