The role of astragaloside in regeneration of the peripheral nerve system

被引：47

作者：

Cheng, CY

Yao, CH

Liu, BS

Liu, CJ

Chen, GW

Chen, YS ^{[1
]}

机构：

[1] China Med Univ, Inst Chinese Med Sci, Lab Biomat, Taichung, Taiwan

[2] China Med Univ, Dept Med Radiol Technol, Taichung, Taiwan

[3] Changhua Christian Hosp, Div Neurosurg, Changhua, Taiwan

[4] China Med Univ, Inst Integrat Chinese & Western Med, Taichung, Taiwan

[5] Chung Tai Inst Hlth Sci & Technol, Inst Biomed Engn & Mat Sci, Taichung, Taiwan

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2006年 / 76A卷 / 03期

关键词：

silicone rubber; astragaloside; collagen; peripheral nerve regeneration;

D O I：

10.1002/jbm.a.30249

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The aim of this study was to evaluate peripheral nerve regeneration across a 15-mm gap in the sciatic nerve of the rat, using a silicone rubber nerve guide filled with different concentrations of astragaloside (0, 50, 100, and 200 mu M). Collagen was also filled in the chambers to prevent the astragaloside from leakage. At the end of 8 weeks, animals from the group treated with astragaloside, especially at the concentration of 50 mu M, had a higher rate of successful regeneration across the wide gap, a significantly larger number of myelinated axons, and a greater evoked action potential than the control group. However, the high-dose astragaloside (200 mu M) completely reversed this positive effect of growth-promoting capability and inhibited nerve regeneration. Thus, astragaloside plays a dual role in anastomosis being salutary in aiding the growth of axons in peripheral nerve but also detrimental, terminating the nerve regenerative processes if improperly applied. (C) 2005 Wiley Periodicals, Inc.

引用

页码：463 / 469

页数：7