Interactions and Potential Implications of Plasmodium falciparum-Hookworm Coinfection in Different Age Groups in South-Central Cote d'Ivoire

被引:42
作者
Righetti, Aurelie A. [1 ,2 ]
Glinz, Dominik [3 ]
Adiossan, Lukas G. [4 ]
Koua, Ahou-Yah G. [5 ]
Niamke, Sebastien [5 ]
Hurrell, Richard F. [3 ]
Wegmueller, Rita [3 ]
N'Goran, Eliezer K. [5 ,6 ]
Utzinger, Juerg [1 ,2 ]
机构
[1] Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland
[2] Univ Basel, Basel, Switzerland
[3] ETH, Inst Food Nutr & Hlth, Human Nutr Lab, Zurich, Switzerland
[4] Hop Gen Taabo, Taabo Cite, Cote Ivoire
[5] Univ Cocody, Unite Format & Rech Biosci, Abidjan, Cote Ivoire
[6] Ctr Suisse Rech Sci Cote Ivoire, Abidjan, Cote Ivoire
来源
PLOS NEGLECTED TROPICAL DISEASES | 2012年 / 6卷 / 11期
基金
瑞士国家科学基金会;
关键词
SOLUBLE TRANSFERRIN RECEPTOR; RETINOL-BINDING-PROTEIN; VITAMIN-A-DEFICIENCY; HELMINTH INFECTIONS; IMMUNE-RESPONSES; MALARIA; ANEMIA; CHILDREN; PREVALENCE; MORBIDITY;
D O I
10.1371/journal.pntd.0001889
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Given the widespread distribution of Plasmodium and helminth infections, and similarities of ecological requirements for disease transmission, coinfection is a common phenomenon in sub-Saharan Africa and elsewhere in the tropics. Interactions of Plasmodium falciparum and soil-transmitted helminths, including immunological responses and clinical outcomes of the host, need further scientific inquiry. Understanding the complex interactions between these parasitic infections is of public health relevance considering that control measures targeting malaria and helminthiases are going to scale. Methodology: A cross-sectional survey was carried out in April 2010 in infants, young school-aged children, and young nonpregnant women in south-central Cote d'Ivoire. Stool, urine, and blood samples were collected and subjected to standardized, quality-controlled methods. Soil-transmitted helminth infections were identified and quantified in stool. Finger-prick blood samples were used to determine Plasmodium spp. infection, parasitemia, and hemoglobin concentrations. Iron, vitamin A, riboflavin, and inflammation status were measured in venous blood samples. Principal Findings: Multivariate regression analysis revealed specific association between infection and demographic, socioeconomic, host inflammatory and nutritional factors. Non-pregnant women infected with P. falciparum had significantly lower odds of hookworm infection, whilst a significant positive association was found between both parasitic infections in 6- to 8-year-old children. Coinfected children had lower odds of anemia and iron deficiency than their counterparts infected with P. falciparum alone. Conclusions/Significance: Our findings suggest that interaction between P. falciparum and light-intensity hookworm infections vary with age and, in school-aged children, may benefit the host through preventing iron deficiency anemia. This observation warrants additional investigation to elucidate the mechanisms and consequences of coinfections, as this information could have important implications when implementing integrated control measures against malaria and helminthiases.
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页数:10
相关论文
共 55 条
[1]  
[Anonymous], 1997, VIT SUPPL GUID THEIR
[2]  
[Anonymous], 2001, IRON DEFICIENCY ANEM, P114
[3]  
[Anonymous], 2007, Country Reports on HNP and Poverty
[4]   Diagnosis, Clinical Features, and Self-Reported Morbidity of Strongyloides stercoralis and Hookworm Infection in a Co-Endemic Setting [J].
Becker, Soeren L. ;
Sieto, Benjamin ;
Silue, Kigbafori D. ;
Adjossan, Lucas ;
Kone, Siaka ;
Hatz, Christoph ;
Kern, Winfried V. ;
N'Goran, Eliezer K. ;
Utzinger, Juerg .
PLOS NEGLECTED TROPICAL DISEASES, 2011, 5 (08)
[5]   Epidemiology of plasmodium-helminth co-infection in Africa: Populations at risk, potential impact on anemia, and prospects for combining control [J].
Brooker, Simon ;
Akhwale, Willis ;
Pullan, Rachel ;
Estambale, Benson ;
Clarke, Sian E. ;
Snow, Robert W. ;
Hotez, Peter J. .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2007, 77 (06) :88-98
[6]   The co-distribution of Plasmodium falciparum and hookworm among African schoolchildren [J].
Brooker, Simon ;
Clements, Archie C. A. ;
Hotez, Peter J. ;
Hay, Simon I. ;
Tatem, Andrew J. ;
Bundy, Donald A. P. ;
Snow, Robert W. .
MALARIA JOURNAL, 2006, 5 (1)
[7]   Confirmation of the protective effect of Ascaris lumbricoides on Plasmodium falciparum infection:: Results of a randomized trial in Madagascar [J].
Brutus, Laurent ;
Watier, Laurence ;
Hanitrasoarnampionona, Virginie ;
Razanatsoarilala, Helene ;
Cot, Michel .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2007, 77 (06) :1091-1095
[8]   Early nonspecific immune responses and immunity to blood-stage nonlethal Plasmodium yoelii malaria [J].
Choudhury, HR ;
Sheikh, NA ;
Bancroft, GJ ;
Katz, DR ;
De Souza, JB .
INFECTION AND IMMUNITY, 2000, 68 (11) :6127-6132
[9]   SERUM TRANSFERRIN RECEPTOR [J].
COOK, JD ;
SKIKNE, BS ;
BAYNES, RD .
ANNUAL REVIEW OF MEDICINE, 1993, 44 :63-74
[10]   Soil-transmitted helminth infections: updating the global picture [J].
de Silva, NR ;
Brooker, S ;
Hotez, PJ ;
Montresor, A ;
Engels, D ;
Savioli, L .
TRENDS IN PARASITOLOGY, 2003, 19 (12) :547-551