Cognitive impairments in relapsing-remitting multiple sclerosis: a meta-analysis

被引：157

作者：

Prakash, R. S. ^{[1
,2
]}

Snook, E. M. ^{[3
]}

Lewis, J. M. ^{[1
,2
]}

Motl, R. W. ^{[3
]}

Kramer, A. F. ^{[1
,2
]}

机构：

[1] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Psychol, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2008年 / 14卷 / 09期

关键词：

cognition; disease subtype; meta-analysis; relapsing-remitting multiple sclerosis;

D O I：

10.1177/1352458508095004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is debate in the literature regarding the magnitude, nature, and influence of cognitive impairment in individuals with relapsing-remitting multiple sclerosis (RRMS). Therefore, we conducted a meta-analysis that quantified the overall magnitude of cognitive impairment in individuals with RRMS and identified the domains of cognition and clinical/demographic variables that were moderators of the overall effect. We included 57 studies with 3891 participants that yielded a total of 755 effect sizes. Overall, there was a moderate decline in cognitive functioning in individuals with RRMS compared with healthy controls. Larger effects were observed in cognitive domains of motor functioning, mood status and memory and learning. Regarding demographic and clinical variables, age and gender were moderators of cognitive impairment in all cognitive domains, whereas neurological disability and disease duration primarily moderated performance on tasks assessing memory and learning. Multiple Sclerosis 2008; 14: 1250-1261. http://msj.sagepub.com

引用

页码：1250 / 1261

页数：12

共 100 条

[1] Cognitive changes in early MS: A call for a common framework [J].

Achiron, A. ;

Barak, Y. .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2006, 245 (1-2) :47-51

[2] COGNITIVE IMPAIRMENT IN EARLY-ONSET MULTIPLE-SCLEROSIS - PATTERN, PREDICTORS, AND IMPACT ON EVERYDAY LIFE IN A 4-YEAR FOLLOW-UP [J].

AMATO, MP ;

PONZIANI, G ;

PRACUCCI, G ;

BRACCO, L ;

SIRACUSA, G ;

AMADUCCI, L .

ARCHIVES OF NEUROLOGY, 1995, 52 (02) :168-172

[3] Cognitive profile of patients with relapsing remitting multiple sclerosis [J].

Andrade, VM ;

Bueno, OFA ;

Oliveira, MGM ;

Oliveira, ASB ;

Oliveira, EML ;

Miranda, MC .

ARQUIVOS DE NEURO-PSIQUIATRIA, 1999, 57 (3B) :775-783

[4] Semantic relations and repetition of items enhance the free recall of words by multiple sclerosis patients [J].

Andrade, VM ;

Oliveira, MGM ;

Miranda, MC ;

Oliveira, ASB ;

Oliveira, EML ;

Bueno, OFA .

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 2003, 25 (08) :1070-1078

[5]

Archibald CJ, 2000, J CLIN EXP NEUROPSYC, V22, P686, DOI 10.1076/1380-3395(200010)22:5

[6]

1-9

[7]

FT686

[8] Conduction aphasia in multiple sclerosis: A case report with MRI findings [J].

Arnett, PA ;

Rao, SM ;

Hussain, M ;

Swanson, SJ ;

Hammeke, TA .

NEUROLOGY, 1996, 47 (02) :576-578

[9] Executive functions in multiple sclerosis: An analysis of temporal ordering, semantic encoding, and planning abilities [J].

Arnett, PA ;

Rao, SM ;

Grafman, J ;

Bernardin, L ;

Luchetta, T ;

Binder, JR ;

Lobeck, L .

NEUROPSYCHOLOGY, 1997, 11 (04) :535-544

[10] Narrative discourse in multiple sclerosis: An investigation of conceptual structure [J].

Arnott, WL ;

Jordan, FM ;

Murdoch, BE ;

Lethlean, JB .

APHASIOLOGY, 1997, 11 (10) :969-991

← 1 2 3 4 5 6 7 8 9 10 →