Therapeutic effects of mesenchymal stem cells on renal ischemia-reperfusion injury: a matter of genetic transfer?

被引：8

作者：

Bruno, Stefania ^{[1
]}

Bussolati, Benedetta ^{[1
]}

机构：

[1] Univ Turin, Dept Mol Biotechnol & Life Sci, Ctr Mol Biotechnol, I-10126 Turin, Italy

来源：

STEM CELL RESEARCH & THERAPY | 2013年 / 4卷

关键词：

MICROVESICLES PROTECT;

D O I：

10.1186/scrt205

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Accumulating evidence indicates that the protective effect of mesenchymal stem cells in models of tissue injury is related to the endocrine/paracrine release of factors. The delivery of growth factors, cytokines, prostaglandins, enzymes or extracellular vesicles from mesenchymal stem cells to target cells may induce cell reprogramming and de novo expression of factors involved in tissue proliferation and repair. A recent paper showed that Wharton jelly derived mesenchymal stem cells interact with injured renal tubular epithelial cells, inducing the expression of native and foreign hepatocyte growth factor necessary for renal repair and fibrogenesis inhibition. The genetic exchange between resident and mesenchymal stem cells, probably mediated through microvesicles, therefore appears instrumental in mesenchymal stem cell therapeutic effects.

引用

页数：2

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