Organ apoptosis in the septic patient: A potential therapeutic target?

被引：12

作者：

Moldawer, LL ^{[1
]}

机构：

[1] Univ Florida, Coll Med, Gainesville, FL 32611 USA

来源：

CRITICAL CARE MEDICINE | 1999年 / 27卷 / 07期

关键词：

SIRS; CARS; septic shock; cytokines; caspase; BCL-2; apoptosis; sepsis; multiple organ dysfunction;

D O I：

10.1097/00003246-199907000-00035

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

引用

页码：1381 / 1382

页数：2

共 13 条

[1] Differential induction of apoptosis in lymphoid tissues during sepsis: Variation in onset, frequency, and the nature of the mediators [J].

Ayala, A ;

Herdon, CD ;

Lehman, DL ;

Ayala, CA ;

Chaudry, IH .

BLOOD, 1996, 87 (10) :4261-4275

[2]

Baue AE, 1997, ARCH SURG-CHICAGO, V132, P703

[3] Sir Isaac Newton, sepsis, SIRS, and CARS [J].

Bone, RC .

CRITICAL CARE MEDICINE, 1996, 24 (07) :1125-1128

[4] Animal models of sepsis and shock: A review and lessons learned [J].

Deitch, EA .

SHOCK, 1998, 9 (01) :1-11

[5] Caspase-3-dependent organ apoptosis early after burn injury [J].

Fukuzuka, K ;

Rosenberg, JJ ;

Gaines, GC ;

Edwards, CK ;

Clare-Salzler, M ;

MacKay, SLD ;

Moldawer, LL ;

Copeland, EM ;

Mozingo, DW .

ANNALS OF SURGERY, 1999, 229 (06) :851-858

[6] Inhibition of human caspases by peptide-based and macromolecular inhibitors [J].

Garcia-Calvo, M ;

Peterson, EP ;

Leiting, B ;

Ruel, R ;

Nicholson, DW ;

Thornberry, NA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (49) :32608-32613

[7] Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway [J].

Hiramatsu, M ;

Hotchkiss, RS ;

Karl, IE ;

Buchman, TG .

SHOCK, 1997, 7 (04) :247-253

[8] Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction [J].

Hotchkiss, RS ;

Swanson, PE ;

Freeman, BD ;

Tinsley, KW ;

Cobb, JP ;

Matuschak, GM ;

Buchman, TG ;

Karl, IE .

CRITICAL CARE MEDICINE, 1999, 27 (07) :1230-1251

[9]

Hotchkiss RS, 1999, J IMMUNOL, V162, P4148

[10] Apoptosis in lymphoid and parenchymal cells during sepsis: Findings in normal and T- and B-cell-deficient mice [J].

Hotchkiss, RS ;

Swanson, PE ;

Cobb, JP ;

Jacobson, A ;

Buchman, TG ;

Karl, IE .

CRITICAL CARE MEDICINE, 1997, 25 (08) :1298-1307

← 1 2 →