Hypotensive but not normotensive haemorrhage increases tryptophan hydroxylase-2 mRNA in caudal midline medulla

被引：12

作者：

Brown, Heidi J.

Henderson, Luke A.

Keay, Kevin A. ^{[1
]}

机构：

[1] Univ Sydney, Royal N Shore Hosp, Pain Management Res Inst, St Leonards, NSW 2065, Australia

[2] Univ Sydney, Sch Med, Dept Anat & Histol, Sydney, NSW 2006, Australia

来源：

NEUROSCIENCE LETTERS | 2006年 / 398卷 / 03期

基金：

英国医学研究理事会;

关键词：

shock; blood loss; serotonin; medullary raphe; hypotension; bradycardia;

D O I：

10.1016/j.neulet.2006.01.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Severe blood loss triggers shock, a precipitous hypotension and bradycardia. The integrity of (i) neurons in the vasodepressor region of the caudal midline medulla and (ii) central 5-HT neurotransmission are critical for the expression of haemorrhagic shock. This study investigated whether progressive blood loss triggers altered synthesis of 5-HT in the vasodepressor region of the caudal midline medulla by measuring changes in relative expression levels of tryptophan hydroxylase 2 (TpH 2) mRNA, the rate-limiting enzyme in the synthesis of neuronal 5-HT. Hypotensive but not normotensive haemorrhage triggered a significant increase in TpH 2 mRNA in the vasodepressor region of the caudal midline medulla, identifying an important role for 5-HT-containing caudal midline medullary neurons in haemorrhagic shock. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：314 / 318

页数：5

共 28 条

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