Characterization of the main radical and products resulting from a reductive activation of the antimalarial arteflene (Ro 42-1611)

被引：31

作者：

Cazelles, J ^{[1
]}

Robert, A ^{[1
]}

Meunier, B ^{[1
]}

机构：

[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 18期

关键词：

D O I：

10.1021/jo990744z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The peroxide-containing antimalarial drug arteflene (Ro 42-1611) generates an alkyl radical after the reductive homolytic cleavage of the peroxide bond in the presence of a heme model Mn-II(TPP). This alkyl radical has been trapped by TEMPO, and the different products of the reduction activation of arteflene have been characterized. These data suggest that, in these experimental conditions, arteflene is not a significant alkylating agent compared to artemisinin, a trioxane-containing antimalarial drug.

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页码：6776 / 6781

页数：6

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