Iron-Catalyzed Enyne Cross-Coupling Reaction

被引：85

作者：

Hatakeyama, Takuji ^{[1
]}

Yoshimoto, Yuya ^{[1
]}

Gabriel, Toma ^{[1
]}

Nakamura, Masaharu ^{[1
]}

机构：

[1] Kyoto Univ, Inst Chem Res, Int Res Ctr Elements Sci, Kyoto 6110011, Japan

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 23期

关键词：

D O I：

10.1021/ol8020226

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of 0.5-1 mol % of FeCl3 with lithium bromide as a crucial additive, alkynyl Grignard reagents, prepared from the corresponding alkynes and methylmagnesium bromide, react with alkenyl bromides or triflates to give the corresponding conjugated enynes in high to excellent yields. The reaction shows wide applicability to various terminal alkynes and alkenyl electrophiles.

引用

页码：5341 / 5344

页数：4

共 13 条

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