An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: Emerging 'Novel Psychoactive Drugs'

被引：26

作者：

Arunotayanun, Warunya ^{[1
]}

Dalley, Jeffrey W. ^{[2
]}

Huang, Xi-Ping ^{[3
,4
,5
]}

Setola, Vincent ^{[3
,4
,5
]}

Treble, Ric ^{[6
]}

Iversen, Leslie ^{[7
]}

Roth, Bryan L. ^{[3
,4
,5
]}

Gibbons, Simon ^{[1
]}

机构：

[1] UCL Sch Pharm, Dept Pharmaceut & Biol Chem, London WC1N 1AX, England

[2] Univ Cambridge, Dept Psychol, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England

[3] Univ N Carolina, Chapel Hill Med Sch, Dept Pharmacol, Program Neurosci, Chapel Hill, NC 27514 USA

[4] Univ N Carolina, Chapel Hill Med Sch, Div Chem Biol & Med Chem, Chapel Hill, NC 27514 USA

[5] Univ N Carolina, Chapel Hill Med Sch, Natl Inst Mental Hlth, Psychoact Drug Screening Program, Chapel Hill, NC 27514 USA

[6] LGC Forens, London TW11 0LY, England

[7] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 11期

关键词：

Tryptamines; Alpha-methyl-tryptamine; 5-Methoxy-N; N-diallyl-tryptamine; LSD; Novel Psychoactive Drugs (NPD); LEGAL HIGHS;

D O I：

10.1016/j.bmcl.2013.03.066

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Novel Psychoactive Drugs (NPD) can be sold without restriction and are often synthetic analogues of controlled drugs. The tryptamines are an important class of NPD as they bind to the various serotonin (5-HT) receptor subtypes and cause psychosis and hallucinations that can lead to injury or death through misadventure. Here we report on the structure elucidation and receptor binding profiles of two widely marketed tryptamine-derived NPDs, namely alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine. (C) 2013 Published by Elsevier Ltd.

引用

页码：3411 / 3415

页数：5

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