Effect of estradiol metabolites on the susceptibility of low density lipoprotein to oxidation

被引：34

作者：

Seeger, H ^{[1
]}

Mueck, AO ^{[1
]}

Lippert, TH ^{[1
]}

机构：

[1] UNIV TUBINGEN,FRAUENKLIN,DEPT OBSTET & GYNECOL,CLIN PHARMACOL SECT,D-72076 TUBINGEN,GERMANY

来源：

LIFE SCIENCES | 1997年 / 61卷 / 09期

关键词：

estradiol metabolites; LDL oxidation;

D O I：

10.1016/S0024-3205(97)00588-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The main estradiol metabolites 2-hydroxyestrone, 2-methoxyestrone and 16 alpha-hydroxyestrone were investigated in vitro for the susceptibility of low density lipoprotein to oxidation and the effects compared with those of estradiol and vitamin E. 2-hydroxyestrone and 2-methoxyestrone had a greater inhibitory effect than estradiol and vitamin E whereas 16 alpha-hydroxyestrone approximates the inhibition of estradiol. These results indicate that 2-hydroxyestrone and 2-methoxyestrone possess non-genomic actions which may play a role in the lipid metabolism.

引用

页码：865 / 868

页数：4

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