Acne - An overview of clinical research findings

Although acne represents the most common chronic skin condition seen by dermatologists, there are still many unanswered questions regarding its pathophysiology, and patients are still in need of more effective therapies, particularly those aimed at the hormonal aspects of acne. This article highlights recent clinical research findings that have led to advances in our understanding of the psychosocial aspects of acne,its pathophysiology, and its treatment. Studies on factors involved in follicular hyperkeratinization, the role of androgens in acne, the emergence and significance of antibiotic resistance of Propionibacterium acnes, the long-term safety and efficacy of isotretinion, and the safety and efficacy of new topical retinoids such as tazarotene and adapalene are presented. Fruitful interactions between basic scientists and clinical researchers within medicine and the pharmaceutical industry will hopefully lead to future advances in this area.