The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients

被引：38

作者：

Salloway, S ^{[1
]}

Boyle, PA ^{[1
]}

Correia, S ^{[1
]}

Malloy, PF ^{[1
]}

Cahn-Weiner, DA ^{[1
]}

Schneider, L ^{[1
]}

Krishnan, KRR ^{[1
]}

Nakra, R ^{[1
]}

机构：

[1] Butler Hosp, Dept Neurol, Providence, RI 02906 USA

来源：

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 2002年 / 10卷 / 01期

关键词：

D O I：

10.1176/appi.ajgp.10.1.107

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The authors examined differences in antidepressant treatment response in geriatric outpatients with high vs. low levels of magnetic resonance imaging (MRI)-defined subcortical hyperintensities (SH). Participants included 59 outpatients with mild-to-moderate depression (mean age: 69 +/- 5.63 years; mean Hamilton Rating Scale for Depression score: 21 +/- 2.88) who participated in a placebo-controlled trial of sertraline and underwent a standardized brain MRI. Results revealed that The high-SH group was significantly older than the low-SH group but, contrary to the hypothesis, antidepressant treatment response did not differ between the high- and low-SH groups. The association between SH and antidepressant treatment response in depressed geriatric outpatients remains unclear and deserves further investigation.

引用

页码：107 / 111

页数：5

共 10 条

[1] INCIDENTAL SUBCORTICAL LESIONS IDENTIFIED ON MAGNETIC-RESONANCE-IMAGING IN THE ELDERLY .1. CORRELATION WITH AGE AND CEREBROVASCULAR RISK-FACTORS [J].