Normal and transforming functions of RUNX1: A perspective

被引：49

作者：

Mikhail, FM

Sinha, KK

Saunthararajah, Y

Nucifora, G

机构：

[1] Univ Illinois, Dept Pathol, Chicago, IL 60607 USA

[2] Univ Illinois, Dept Med, Chicago, IL 60607 USA

[3] Univ Alabama Birmingham, Dept Genet, Birmingham, AL USA

[4] Univ Alexandria, Fac Med, Dept Clin Pathol, Alexandria, Egypt

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2006年 / 207卷 / 03期

关键词：

D O I：

10.1002/jcp.20538

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Converging studies from many investigators indicate that RUNX1 has a critical role in the correct maintenance of essential cellular functions during embryonic development and after birth. The discovery that this gene is also frequently mutated in human leukemia has increased the interest in the role that RUNX1 plays in both normal and transforming pathways. Here, we provide an overview of the many roles of RUNX1 in hematopoietic self-renewal and differentiation and summarize the information that is currently available on the many mechanisms of RUNX1 deregulation in human leukemia.

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页码：582 / 593

页数：12

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