β-lactamase-mediated resistance to extended spectrum cephalosporins among clinical isolates of Pseudomonas aeruginosa

被引：17

作者：

Ben-Mahrez, K ^{[1
]}

Rejiba, S ^{[1
]}

Belhadj, C ^{[1
]}

Belhadj, O ^{[1
]}

机构：

[1] Fac Sci Tunis, Lab Biochim & Technobiol, Tunis 1060, Tunisia

来源：

RESEARCH IN MICROBIOLOGY | 1999年 / 150卷 / 06期

关键词：

beta-lactam antibiotic; beta-lactamase; cephalosporinase; Pseudomonas aeruginosa;

D O I：

10.1016/S0923-2508(99)80075-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The role of chromosomal cephalosporinases and secondary beta-lactamases in resistance to extended spectrum cephalosporins in clinical isolates of Pseudomonas aeruginosa was investigated. Strains 687, 59, and 58 expressed an inducible chromosomal cephalosporinase, efficiently enhanced with cefoxitin and imipenem. The inducible activity in strain 802 was produced at a moderately elevated basal level and may be involved in resistance to extended spectrum cephalosporins and aztreonam. All strains produced secondary beta-lactamases inhibited by clavulanate: strains 687, 59, and 58 had carbenicillinases with pIs of 5.7 and 5.3. Strain 802 expressed a secondary beta-lactamase of pI 7.6 which may be a novel extended spectrum beta-lactamase different from known enzymes of P. aeruginosa. (C) Elsevier, Paris.

引用

页码：403 / 406

页数：4

共 13 条

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