Retrograde transport of cholera toxin into the ER of host cells

被引：22

作者：

Lencer, WI

机构：

[1] Childrens Hosp, Harvard Digest Dis Ctr, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2004年 / 293卷 / 7-8期

关键词：

cholera toxin; lipid rafts; membrane transport; endoplasmic reticulum; Golgi;

D O I：

10.1078/1438-4221-00293

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cholera toxin moves from the plasma membrane to the ER of host cells to cause disease. Here we discuss recent studies on the mechanism of transport from plasma membrane to the ER and on the reactions that unfold and retrotranslocate a portion of the toxin to the cytosol where toxicity is induced.

引用

收藏

页码：491 / 494

页数：4

相关论文

共 23 条

[1] Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process [J].

Abrami, L ;

Liu, SH ;

Cosson, P ;

Leppla, SH ;

van der Goot, FG .

JOURNAL OF CELL BIOLOGY, 2003, 160 (03) :321-328

[2]

Arab S, 1998, J CELL PHYSIOL, V177, P646, DOI 10.1002/(SICI)1097-4652(199812)177:4<646::AID-JCP15>3.0.CO

[3]

2-B

[4] Imaging the intracellular trafficking and state of the AB(5) quaternary structure of cholera toxin [J].

Bastiaens, PIH ;

Majoul, IV ;

Verveer, PJ ;

Soling, HD ;

Jovin, TM .

EMBO JOURNAL, 1996, 15 (16) :4246-4253

[5] Targeting of shiga toxin B-subunit to retrograde transport route in association with detergent-resistant membranes [J].

Falguières, T ;

Mallard, F ;

Baron, C ;

Hanau, D ;

Lingwood, C ;

Goud, B ;

Salamero, J ;

Johannes, L .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (08) :2453-2468

[6] Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm [J].

Fujinaga, Y ;

Wolf, AA ;

Rodighiero, C ;

Wheeler, H ;

Tsai, B ;

Allen, L ;

Jobling, MG ;

Rapoport, T ;

Holmes, RK ;

Lencer, WI .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (12) :4783-4793

[7] Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum [J].

Girod, A ;

Storrie, B ;

Simpson, JC ;

Johannes, L ;

Goud, B ;

Roberts, LM ;

Lord, JM ;

Nilsson, T ;

Pepperkok, R .

NATURE CELL BIOLOGY, 1999, 1 (07) :423-430

[8] Dynamin-mediated internalization of caveolae [J].

Henley, JR ;

Krueger, EWA ;

Oswald, BJ ;

McNiven, MA .

JOURNAL OF CELL BIOLOGY, 1998, 141 (01) :85-99

[9] KDEL receptor (Erd2p)-mediated retrograde transport of the cholera toxin A subunit from the Golgi involves COPI, p23, and the COOH terminus of Erd2p [J].

Majoul, I ;

Sohn, K ;

Wieland, FT ;

Pepperkok, R ;

Pizza, M ;

Hillemann, J ;

Söling, HD .

JOURNAL OF CELL BIOLOGY, 1998, 143 (03) :601-612

[10] KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic:: Measurements in living cells using FRET [J].

Majoul, I ;

Straub, M ;

Hell, SW ;

Duden, R ;

Söling, HD .

DEVELOPMENTAL CELL, 2001, 1 (01) :139-153