Allelic loss of 9p21.3 is a prognostic factor in 1p/19q codeleted anaplastic gliomas

被引：35

作者：

Alentorn, Agusti ^{[1
,2
,3
,4
,5
,6
]}

Dehais, Caroline ^{[1
]}

Ducray, Francois ^{[7
,8
]}

Carpentier, Catherine ^{[3
,4
,5
,6
]}

Mokhtari, Karima ^{[3
,4
,5
,6
,9
]}

Figarella-Branger, Dominique ^{[10
,11
]}

Chinot, Olivier ^{[12
]}

Cohen-Moyal, Elisabeth ^{[13
,14
]}

Ramirez, Carole ^{[15
]}

Loiseau, Hugues ^{[16
]}

Elouahdani-Hamdi, Selma ^{[16
,17
]}

Beauchesne, Patrick ^{[18
]}

Langlois, Olivier ^{[19
]}

Desenclos, Christine ^{[20
]}

Guillamo, Jean-Sebastien ^{[21
]}

Dam-Hieu, Phong ^{[22
]}

Ghiringhelli, Francois ^{[23
]}

Colin, Philippe ^{[24
]}

Godard, Joel ^{[1
,25
]}

Parker, Fabrice ^{[26
]}

Dhermain, Frederic ^{[27
]}

Carpentier, Antoine F. ^{[28
]}

Frenel, Jean-Sebastien ^{[29
]}

Menei, Philippe ^{[30
]}

Bauchet, Luc ^{[31
]}

Faillot, Thierry ^{[32
]}

Fesneau, Melanie ^{[33
]}

Fontaine, Denys ^{[34
]}

Motuo-Fotso, Marie-Jeannette ^{[35
]}

Vauleon, Elodie ^{[36
]}

Gaultier, Claude ^{[37
]}

Le Guerinel, Caroline ^{[38
]}

Gueye, Edouard-Marcel ^{[39
]}

Noel, Georges ^{[40
]}

Desse, Nicolas ^{[41
]}

Durando, Xavier ^{[42
]}

Barrascout, Eduardo ^{[43
]}

Wager, Michel ^{[44
]}

Ricard, Damien ^{[45
]}

Carpiuc, Ioana ^{[46
]}

Delattre, Jean-Yves ^{[1
,2
,3
,4
,5
,6
]}

Idbaih, Ahmed ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Grp Hosp Pitie Salpetriere, AP HP, Serv Neurol Mazarin 2, F-75634 Paris, France

[2] Univ Paris 04, F-75230 Paris 05, France

[3] Univ Paris 06, UM 75, Paris, France

[4] INSERM, ICM, U 1127, Paris, France

[5] CNRS, ICM, UMR 7225, Paris, France

[6] ICM, Paris, France

[7] Hosp Civils Lyon, Hop Neurol, Lyon Neurosci Res Ctr, CNRS UMR 5292,INSERM U1028, Bron, France

[8] Univ Lyon 1, Serv Neurooncol, Bron, France

[9] Univ Paris 04, Serv Neuropathol Raymond Escourolle, Grp Hosp Pitie Salpetriere, AP HP, F-75230 Paris 05, France

[10] Aix Marseille Univ, Hop la Timone, Assistance Publ Hop Marseille, Fac Med la Timone, Marseille, France

[11] INSERM, Serv Pathol & Neuropathol, UMR S CRO2 911, F-13258 Marseille, France

[12] Serv Neurooncol, Marseille, France

[13] Inst Claudius Regaud, Toulouse, France

[14] INSERM, Serv Radiotherapie, U1037, Toulouse, France

[15] CHU Lille, Serv Neurochirurg, F-59037 Lille, France

[16] CHU Bordeaux GH Pellegrin, Serv Neurochirurg, Bordeaux, France

[17] CHU Lariboisiere, AP HP, Serv Neurochirurg, Paris, France

[18] CHU Nancy, Serv Neurooncol, Nancy, France

[19] CHU Charles Nicolle, Serv Neurochirurg, Rouen, France

[20] CHU Amiens, Hop Nord, Serv Neurochirurg, Amiens, France

[21] CHU Caen, Serv Neurol, F-14000 Caen, France

[22] CHU Brest, Hop Cavale Blanche, Serv Neurochirurg, Brest, France

[23] Ctr Georges Francois Leclerc, Med Oncol Serv, Dijon, France

[24] Clin Courlancy, Serv Radiotherapie, Reims, France

[25] CHU Besancon, Hop Jean Minjoz, Serv Neurochirurg, F-25030 Besancon, France

[26] CHU Bicetre, AP HP, Serv Neurochirurg, Le Kremlin Bicetre, France

[27] Inst Gustave Roussy, Serv Radiotherapie, Villejuif, France

[28] CHU Avicenne, AP HP, Serv Neurol, Bobigny, France

[29] CLCC Rene Gauducheau, Inst Cancerol Ouest, Med Oncol Serv, St Herblain, France

[30] CHU Angers, Serv Neurochirurg, Angers, France

[31] CHU Montpellier, Serv Neurochirurg, Montpellier, France

[32] CHU Beaujon, AP HP, Serv Neurochirurg, Clichy, France

[33] CHR Orleans, Serv Radiotherapie, Orleans, France

[34] CHU Nice, Serv Neurochirurg, F-06202 Nice, France

[35] CHU St Etienne, Hop Nord, St Priest En Jarez, France

[36] Ctr Eugene Marquis, Med Oncol Serv, Rennes, France

[37] CH Colmar, Serv Neurol, Colmar, France

[38] CHU Henri Mondor, Serv Neurochirurg, F-94010 Creteil, France

[39] CHU Limoges, Hop Dupuytren, Serv Neurochirurg, Limoges, France

[40] Ctr Paul Strauss, Serv Radiotherapie, Strasbourg, France

[41] HIA St Anne, Serv Neurochirurg, Toulon, France

[42] Ctr Jean Perrin, Med Oncol Serv, Clermont Ferrand, France

[43] Hop Foch, Med Oncol Serv, Suresnes, France

[44] CHU Poitiers, Serv Neurochirurg, Poitiers, France

[45] HIA Val de Grace, Serv Neurol, Paris, France

[46] Clin Cedres, Med Oncol Serv, Cornebarrieu, France

来源：

NEUROLOGY | 2015年 / 85卷 / 15期

关键词：

COPY NUMBER; MUTATIONS; ARRAYS;

D O I：

10.1212/WNL.0000000000002014

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objectives:We aimed to study the potential clinical relevance of 9p allelic loss, with or without copy number variation, in 1p/19q codeleted anaplastic oligodendroglial tumors (AOTs).Methods:This study enrolled 216 patients with 1p/19q codeleted AOT. The prognostic value of 9p allelic loss was investigated using a French nation-wide prospective registry, POLA (prise en charge des tumeurs oligodendrogliales anaplasiques) and high-density single nucleotide polymorphism arrays. We validated our results using the Repository of Molecular Brain Neoplasia Data (REMBRANDT) dataset.Results:The minimal common region of allelic loss in chromosome arm 9p was 9p21.3. Allelic loss of 9p21.3, detected in 41.7% of tumors, was associated with shorter progression-free and overall survival rates in univariate (p = 0.008 and p < 0.001, respectively) and multivariate analyses (p = 0.009 and p = 0.009, respectively). This finding was validated in the REMBRANDT dataset in univariate and multivariate analysis (p = 0.01 and p = 0.01, respectively).Conclusion:Our study highlights a novel potential prognostic biomarker in 1p/19q codeleted AOT. Further prospective studies are warranted to investigate our finding.

引用

页码：1325 / 1331

页数：7

共 17 条

[1]

A single-array preprocessing method for estimating full-resolution raw copy numbers from all Affymetrix genotyping arrays including GenomeWideSNP 5 & 6 [J].

Bengtsson, Henrik ;

Wirapati, Pratyaksha ;

Speed, Terence P. .

BIOINFORMATICS, 2009, 25 (17) :2149-2156

[2]

Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma [J].

Bettegowda, Chetan ;

Agrawal, Nishant ;

Jiao, Yuchen ;

Sausen, Mark ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Rodriguez, Fausto J. ;

Cahill, Daniel P. ;

McLendon, Roger ;

Riggins, Gregory ;

Velculescu, Victor E. ;

Oba-Shinjo, Sueli Mieko ;

Marie, Suely Kazue Nagahashi ;

Vogelstein, Bert ;

Bigner, Darell ;

Yan, Hai ;

Papadopoulos, Nickolas ;

Kinzler, Kenneth W. .

SCIENCE, 2011, 333 (6048) :1453-1455

[3]

Phase III Trial of Chemoradiotherapy for Anaplastic Oligodendroglioma: Long-Term Results of RTOG 9402 [J].

Cairncross, Gregory ;

Wang, Meihua ;

Shaw, Edward ;

Jenkins, Robert ;

Brachman, David ;

Buckner, Jan ;

Fink, Karen ;

Souhami, Luis ;

Laperriere, Normand ;

Curran, Walter ;

Mehta, Minesh .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (03) :337-343

[4]

Comprehensive genomic characterization defines human glioblastoma genes and core pathways [J].

Chin, L. ;

Meyerson, M. ;

Aldape, K. ;

Bigner, D. ;

Mikkelsen, T. ;

VandenBerg, S. ;

Kahn, A. ;

Penny, R. ;

Ferguson, M. L. ;

Gerhard, D. S. ;

Getz, G. ;

Brennan, C. ;

Taylor, B. S. ;

Winckler, W. ;

Park, P. ;

Ladanyi, M. ;

Hoadley, K. A. ;

Verhaak, R. G. W. ;

Hayes, D. N. ;

Spellman, Paul T. ;

Absher, D. ;

Weir, B. A. ;

Ding, L. ;

Wheeler, D. ;

Lawrence, M. S. ;

Cibulskis, K. ;

Mardis, E. ;

Zhang, Jinghui ;

Wilson, R. K. ;

Donehower, L. ;

Wheeler, D. A. ;

Purdom, E. ;

Wallis, J. ;

Laird, P. W. ;

Herman, J. G. ;

Schuebel, K. E. ;

Weisenberger, D. J. ;

Baylin, S. B. ;

Schultz, N. ;

Yao, Jun ;

Wiedemeyer, R. ;

Weinstein, J. ;

Sander, C. ;

Gibbs, R. A. ;

Gray, J. ;

Kucherlapati, R. ;

Lander, E. S. ;

Myers, R. M. ;

Perou, C. M. ;

McLendon, Roger .

NATURE, 2008, 455 (7216) :1061-1068

[5]

Splicing into senescence: The curious case of p(16) and p19(ARF) [J].

Haber, DA .

CELL, 1997, 91 (05) :555-558

[6]

SNP Array Analysis Reveals Novel Genomic Abnormalities Including Copy Neutral Loss of Heterozygosity in Anaplastic Oligodendrogliomas [J].

Idbaih, Ahmed ;

Ducray, Francois ;

Dehais, Caroline ;

Courdy, Celia ;

Carpentier, Catherine ;

de Bernard, Simon ;

Uro-Coste, Emmanuelle ;

Mokhtari, Karima ;

Jouvet, Anne ;

Honnorat, Jerome ;

Chinot, Olivier ;

Ramirez, Carole ;

Beauchesne, Patrick ;

Benouaich-Amiel, Alexandra ;

Godard, Joel ;

Eimer, Sandrine ;

Parker, Fabrice ;

Lechapt-Zalcman, Emmanuelle ;

Colin, Philippe ;

Loussouarn, Delphine ;

Faillot, Thierry ;

Phong Dam-Hieu ;

Elouadhani-Hamdi, Selma ;

Bauchet, Luc ;

Langlois, Olivier ;

Le Guerinel, Caroline ;

Fontaine, Denys ;

Vauleon, Elodie ;

Menei, Philippe ;

Fotso, Marie Janette Motsuo ;

Desenclos, Christine ;

Verelle, Pierre ;

Ghiringhelli, Franc Ois ;

Noel, Georges ;

Labrousse, Francois ;

Carpentier, Antoine ;

Dhermain, Frederic ;

Delattre, Jean-Yves ;

Figarella-Branger, Dominique .

PLOS ONE, 2012, 7 (10)

[7]

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal [J].

Killela, Patrick J. ;

Reitman, Zachary J. ;

Jiao, Yuchen ;

Bettegowda, Chetan ;

Agrawal, Nishant ;

Diaz, Luis A., Jr. ;

Friedman, Allan H. ;

Friedman, Henry ;

Gallia, Gary L. ;

Giovanella, Beppino C. ;

Grollman, Arthur P. ;

He, Tong-Chuan ;

He, Yiping ;

Hruban, Ralph H. ;

Jallo, George I. ;

Mandahl, Nils ;

Meeker, Alan K. ;

Mertens, Fredrik ;

Netto, George J. ;

Rasheed, B. Ahmed ;

Riggins, Gregory J. ;

Rosenquist, Thomas A. ;

Schiffman, Mark ;

Shih, Ie-Ming ;

Theodorescu, Dan ;

Torbenson, Michael S. ;

Velculescu, Victor E. ;

Wang, Tian-Li ;

Wentzensen, Nicolas ;

Wood, Laura D. ;

Zhang, Ming ;

McLendon, Roger E. ;

Bigner, Darell D. ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Papadopoulos, Nickolas ;

Yan, Hai .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (15) :6021-6026

[8]

International Society of Neuropathology-Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading [J].

Louis, David N. ;

Perry, Arie ;

Burger, Peter ;

Ellison, David W. ;

Reifenberger, Guido ;

von Deimling, Andreas ;

Aldape, Kenneth ;

Brat, Daniel ;

Collins, V. Peter ;

Eberhart, Charles ;

Figarella-Branger, Dominique ;

Fuller, Gregory N. ;

Giangaspero, Felice ;

Giannini, Caterina ;

Hawkins, Cynthia ;

Kleihues, Paul ;

Korshunov, Andrey ;

Kros, Johan M. ;

Lopes, M. Beatriz ;

Ng, Ho-Keung ;

Ohgaki, Hiroko ;

Paulus, Werner ;

Pietsch, Torsten ;

Rosenblum, Marc ;

Rushing, Elisabeth ;

Soylemezoglu, Figen ;

Wiestler, Otmar ;

Wesseling, Pieter .

BRAIN PATHOLOGY, 2014, 24 (05) :429-435

[9]

Rembrandt: Helping Personalized Medicine Become a Reality through Integrative Translational Research [J].

Madhavan, Subha ;

Zenklusen, Jean-Claude ;

Kotliarov, Yuri ;

Sahni, Himanso ;

Fine, Howard A. ;

Buetow, Kenneth .

MOLECULAR CANCER RESEARCH, 2009, 7 (02) :157-167

[10]

Parent-specific copy number in paired tumor-normal studies using circular binary segmentation [J].

Olshen, Adam B. ;

Bengtsson, Henrik ;

Neuvial, Pierre ;

Spellman, Paul T. ;

Olshen, Richard A. ;

Seshan, Venkatraman E. .

BIOINFORMATICS, 2011, 27 (15) :2038-2046

← 1 2 →