Recent Development in Targeting PI3K-Akt-mTOR Signaling for Anticancer Therapeutic Strategies

被引：42

作者：

Qazi, Asif Khurshid ^{[1
]}

Hussain, Aashiq ^{[1
]}

Hamid, Abid ^{[1
]}

Qurishi, Yasrib ^{[1
]}

Majeed, Rabiya ^{[1
]}

Ahmad, Mudassier ^{[1
]}

Najar, Rauf Ahmad ^{[1
]}

Bhat, Javeed Ahmad ^{[1
]}

Singh, Shashank Kumar ^{[1
]}

Zargar, Mohmmad Afzal ^{[2
]}

Ali, Shakir ^{[3
]}

Saxena, Ajit Kumar ^{[1
]}

机构：

[1] CSIR Indian Inst Integrat Med, Canc Pharmacol Div, Jammu 180001, India

[2] Univ Kashmir, Dept Biochem, Srinagar 190001, Jammu & Kashmir, India

[3] Jamia Hamdard, Dept Biochem, New Delhi 110062, India

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2013年 / 13卷 / 10期

关键词：

Anticancer target; cancer; inhibitors; PI3K-Akt-mTOR; Signaling; therapy; translation; II PHOSPHOINOSITIDE 3-KINASE; PLECKSTRIN HOMOLOGY DOMAIN; BREAST-CANCER; CELL-MIGRATION; DEPENDENT MECHANISM; ANTITUMOR-ACTIVITY; KINASE INHIBITORS; TUMOR SUPPRESSION; LIPID KINASE; PATHWAY;

D O I：

10.2174/1871520613666131125123241

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cancer is a diverse class of diseases which differ widely in their cause and biology. The aberrant behavior of cancer reflects up regulation of certain oncogenic signaling pathways that promote proliferation, inhibit apoptosis, and enable the cancer to spread and evoke angiogenesis. Phosphoinositide-3-kinase(PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway controls various biological processes that are important for normal functioning of the cell via cell cycle progression, survival, migration, transcription, translation and metabolism. However, PI3K signaling pathway is dysregulated almost in all cancers which is due to the amplification and genetic mutation of PI3K gene, encoding catalytic and regulatory subunit of PI3K isoforms. The current review focuses on the structural features of various PI3K isoforms including Akt and mTOR and their inhibition using specific small molecule inhibitors in an attempt to achieve an attractive target for cancer prevention and chemotherapy.

引用

页码：1552 / 1564

页数：13

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