Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease

被引：209

作者：

Kiat, Tan Siew

Pippen, Richard

Yusof, Rohana

Ibrahim, Halijah

Norzulaani, Khalid

Rahman, Noorsaadah Abd ^{[1
]}

机构：

[1] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia

[2] Sunway Univ Coll, PJ Selangor 46150, Malaysia

[3] Western Michigan Univ, Kalamazoo, MI 49008 USA

[4] Univ Malaya, Fac Med, Dept Biochem, Kuala Lumpur 50603, Malaysia

[5] Univ Malaya, Inst Biol Sci, Kuala Lumpur 50603, Malaysia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 12期

关键词：

Boesenbergia rotunda (L.) extracts; cyclohexenyl chalcone derivatives; dengue; 2; NS3; protease; competitive inhibitory activities;

D O I：

10.1016/j.bmcl.2005.12.075

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the K-i values of 21 and 25 mu M, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：3337 / 3340

页数：4

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