Beyond extinction: erasing human fear responses and preventing the return of fear

被引：582

作者：

Kindt, Merel ^{[1
]}

Soeter, Marieke ^{[1
]}

Vervliet, Bram ^{[1
]}

机构：

[1] Univ Amsterdam, Dept Clin Psychol, NL-1018 WB Amsterdam, Netherlands

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 03期

关键词：

POTENTIATED STARTLE; AMYGDALA; RECONSOLIDATION; CONSOLIDATION; RETRIEVAL; MEMORIES;

D O I：

10.1038/nn.2271

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Animal studies have shown that fear memories can change when recalled, a process referred to as reconsolidation. We found that oral administration of the beta-adrenergic receptor antagonist propranolol before memory reactivation in humans erased the behavioral expression of the fear memory 24 h later and prevented the return of fear. Disrupting the reconsolidation of fear memory opens up new avenues for providing a long-term cure for patients with emotional disorders.

引用

页码：256 / 258

页数：3

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