Remodeling for demolition: Changes in mitochrondrial ultrastructure during apoptosis

被引：80

作者：

Reed, JC

Green, DR

机构：

[1] Burnham Inst, La Jolla, CA 92037 USA

[2] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA

来源：

MOLECULAR CELL | 2002年 / 9卷 / 01期

关键词：

D O I：

10.1016/S1097-2765(02)00437-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The release of Cytochrome c from mitochondria is a pivotal event in the apoptotic process, but the precise mechanisms remain controversial. A recent paper proposes that this involves two steps, one involving permeabilization of the mitochondrial outer membrane and a second in which the structural organization of the cristae changes to make Cytochrome c accessible for release. Both events are induced by proapoptotic members of the Bcl-2 family and appear to be separable.

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页码：1 / 3

页数：3

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