Expression pattern of macrophage migration inhibitory factor during embryogenesis

被引:31
作者
Kobayashi, S
Satomura, K
Levsky, JM
Sreenath, T
Wistow, GJ
Semba, I
Shum, L
Slavkin, HC
Kulkarni, AB [1 ]
机构
[1] Funct Genom Unit, Bethesda, MD 20892 USA
[2] Gene Targeting Facil, Bethesda, MD 20892 USA
[3] Natl Inst Dent & Craniofacial Res, Craniofacial & Skeletal Dis Branch, Rockville, MD 20852 USA
[4] NEI, Sect Mol Struct & Funct, Bethesda, MD 20892 USA
[5] NIAMSD, Craniofacial Dev Sect, NIH, Bethesda, MD 20892 USA
关键词
macrophage migration inhibitory factor; cytokine; embryogenesis;
D O I
10.1016/S0925-4773(99)00057-X
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Although macrophage migration inhibitory factor (MIF) was originally identified as a lymphokine that inhibits the migration of macrophages, its ubiquitous expression suggests it may have a role beyond the immune system. Here we report a detailed characterization of MIF expression during mouse embryogenesis. The MIF expression pattern was found to parallel tissues specification and organogenesis. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:153 / 156
页数:4
相关论文
共 10 条
  • [1] IDENTIFICATION OF MIF AS A NEW PITUITARY-HORMONE AND MACROPHAGE CYTOKINE AND ITS ROLE IN ENDOTOXIC-SHOCK
    BUCALA, R
    [J]. IMMUNOLOGY LETTERS, 1994, 43 (1-2) : 23 - 26
  • [2] Imamura K, 1996, BIOCHEM MOL BIOL INT, V40, P1233
  • [3] Nishibori M, 1996, NEUROSCI LETT, V213, P193
  • [4] LOCALIZATION OF MACROPHAGE-MIGRATION INHIBITORY FACTOR (MIF) TO SECRETORY GRANULES WITHIN THE CORTICOTROPIC AND THYROTROPIC CELLS OF THE PITUITARY-GLAND
    NISHINO, T
    BERNHAGEN, J
    SHIIKI, H
    CALANDRA, T
    DOHI, K
    BUCALA, R
    [J]. MOLECULAR MEDICINE, 1995, 1 (07) : 781 - 788
  • [5] SONIC-HEDGEHOG MEDIATES THE POLARIZING ACTIVITY OF THE ZPA
    RIDDLE, RD
    JOHNSON, RL
    LAUFER, E
    TABIN, C
    [J]. CELL, 1993, 75 (07) : 1401 - 1416
  • [6] The immunoregulatory mediator macrophage migration inhibitory factor (MIF) catalyzes a tautomerization reaction
    Rosengren, E
    Bucala, R
    Aman, P
    Jacobsson, L
    Odh, G
    Metz, CN
    Rorsman, H
    [J]. MOLECULAR MEDICINE, 1996, 2 (01) : 143 - 149
  • [7] MINERALIZED NODULE FORMATION IN RAT BONE-MARROW STROMAL CELL-CULTURE WITHOUT BETA-GLYCEROPHOSPHATE
    SATOMURA, K
    HIRAIWA, K
    NAGAYAMA, M
    [J]. BONE AND MINERAL, 1991, 14 (01): : 41 - 54
  • [8] Evidence for the presence of macrophage migration inhibitory factor in murine reproductive organs and early embryos
    Suzuki, H
    Kanagawa, H
    Nishihira, J
    [J]. IMMUNOLOGY LETTERS, 1996, 51 (03) : 141 - 147
  • [9] Augmented expression of macrophage migration inhibitory factor (MIF) in the telencephalon of the developing rat brain
    Suzuki, T
    Ogata, A
    Tashiro, K
    Nagashima, K
    Tamura, M
    Nishihira, J
    [J]. BRAIN RESEARCH, 1999, 816 (02) : 457 - 462
  • [10] A MACROPHAGE-MIGRATION INHIBITORY FACTOR IS EXPRESSED IN THE DIFFERENTIATING CELLS OF THE EYE LENS
    WISTOW, GJ
    SHAUGHNESSY, MP
    LEE, DC
    HODIN, J
    ZELENKA, PS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (04) : 1272 - 1275