Adrenomedullin receptors: molecular identity and function

被引：58

作者：

Hay, DL ^{[1
]}

Smith, DM

机构：

[1] Aston Univ, Sch Life Sci, Birmingham B4 7ET, W Midlands, England

[2] CVGI, AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

PEPTIDES | 2001年 / 22卷 / 11期

基金：

英国医学研究理事会;

关键词：

adrenomedullin receptors; CGRP receptors; CRLR; RAMPs;

D O I：

10.1016/S0196-9781(01)00532-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since its discovery in 1993 adrenomedullin (AM) has been the subject over 600 published articles. This multifunctional peptide has powerful vasodilator actions and recent evidence from AM gene-deleted mice suggest that AM plays an essential role in vascular development. However the lack of valid AM receptor clones and non-peptide receptor ligands has considerably slowed research progress on this important peptide. In this review we have focused on the proposition that the calcitonin receptor-like receptor (CRLR) is a receptor both for AM and the related vasoactive peptide calcitonin gene-related peptide (CGRP). The receptor activity modifying proteins (RAMPS) that are essential for defining CRLR pharmacology will also be discussed. We will describe how AM receptors have been reported to signal and be regulated and to consider whether further receptors for AM beyond CRLR/RAMP combinations might exist. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：1753 / 1763

页数：11

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