Early death of mice cloned from somatic cells

被引：164

作者：

Ogonuki, N

Inoue, K

Yamamoto, Y

Noguchi, Y

Tanemura, K

Suzuki, O

Nakayama, H

Doi, K

Ohtomo, Y

Satoh, M

Nishida, A

Ogura, A ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Vet Sci, Shinjuku Ku, Tokyo, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Pathol, Tokyo, Japan

[3] Tohoku Univ, Fac Agr, Grad Sch Agr Sci, Sendai, Miyagi, Japan

来源：

NATURE GENETICS | 2002年 / 30卷 / 03期

关键词：

D O I：

10.1038/ng841

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Here we report that the lifespan of mice cloned from somatic cells is significantly shorter than that of genotype- and sex-matched controls, most likely due to severe pneumonia and hepatic failure. This finding demonstrates the possibility of long-term deleterious effects of somatic-cell cloning, even after normal birth.

引用

收藏

页码：253 / 254

页数：2

相关论文

共 11 条

[1] Effect of age on respiratory defense mechanisms -: Pulmonary bacterial clearance in fischer 344 rats after intratracheal instillation of Listeria monocytogenes [J].

Antonini, JM ;

Roberts, JR ;

Clarke, RW ;

Yang, HM ;

Barger, MW ;

Ma, JYC ;

Weissman, DN .

CHEST, 2001, 120 (01) :240-249

[2] Pneumonia in the elderly: Overview of diagnostic and therapeutic approaches [J].

Fein, AM .

CLINICAL INFECTIOUS DISEASES, 1999, 28 (04) :726-729

[3] Generation of dwarf coat (Capra hircus) clones following nuclear transfer with transfected and nontransfected fetal fibroblasts and in vitro-matured oocytes [J].

Keefer, CL ;

Baldassarre, H ;

Keyston, R ;

Wang, B ;

Bhatia, B ;

Bilodeau, AS ;

Zhou, JF ;

Leduc, M ;

Downey, BR ;

Lazaris, A ;

Karatzas, CN .

BIOLOGY OF REPRODUCTION, 2001, 64 (03) :849-856

[4]

KIMURA Y, 1995, DEVELOPMENT, V121, P2397

[5]

MILLER RA, 1991, INT REV CYTOL, V124, P187

[6] Production of male cloned mice from fresh, cultured, and cryopreserved immature Sertoli cells [J].

Ogura, A ;

Inoue, K ;

Ogonuki, N ;

Noguchi, A ;

Takano, K ;

Nagano, R ;

Suzuki, O ;

Lee, L ;

Ishino, F ;

Matsuda, J .

BIOLOGY OF REPRODUCTION, 2000, 62 (06) :1579-1584

[7] Lymphoid hypoplasia and somatic cloning [J].

Renard, JP ;

Chastant, S ;

Chesné, P ;

Richard, C ;

Marchal, J ;

Cordonnier, N ;

Chavatte, P ;

Vignon, X .

LANCET, 1999, 353 (9163) :1489-1491

[8] Postnatal growth and behavioral development of mice cloned from adult cumulus cells [J].

Tamashiro, KLK ;

Wakayama, T ;

Blanchard, RJ ;

Blanchard, DC ;

Yanagimachi, R .

BIOLOGY OF REPRODUCTION, 2000, 63 (01) :328-334

[9] Normal telomere lengths found in cloned cattle [J].

Tian, XC ;

Xu, J ;

Yang, XZ .

NATURE GENETICS, 2000, 26 (03) :272-273

[10] Ageing - Cloning of mice to six generations [J].

Wakayama, T ;

Shinkai, Y ;

Tamashiro, KLK ;

Niida, H ;

Blanchard, DC ;

Blanchard, RJ ;

Ogura, A ;

Tanemura, K ;

Tachibana, M ;

Perry, ACF ;

Colgan, DF ;

Mombaerts, P ;

Yanagimachi, R .

NATURE, 2000, 407 (6802) :318-319