Paroxetine for hepatopulmonary syndrome?

被引：4

作者：

Altschuler, EL

Kast, RE

机构：

[1] CUNY Mt Sinai Sch Med, New York, NY 10029 USA

[2] Univ Calif San Diego, Brain & Percept Lab, La Jolla, CA 92093 USA

[3] Univ Vermont, Dept Psychiat, Burlington, VT 05401 USA

来源：

MEDICAL HYPOTHESES | 2004年 / 62卷 / 03期

关键词：

D O I：

10.1016/j.mehy.2003.10.017

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Hepatoputmonary syndrome (HIPS) is a severe pulmonary sequela which can affect up to 15% of patients with cirrhotic liver disease.. There is no treatment for HPS other than liver transplantation. The cause of HPS is incompletely understood, but the pulmonary vasodilation in HPS is thought to,be related to increased levels of nitric oxide. We therefore suggest that, the extremely safe and commonly used antidepressant medication paroxetine (Paxil) which is a potent nitric oxide synthase (NOS) inhibitor be considered for use in HPS. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：446 / 447

页数：2

共 5 条

[1]

Prospective evaluation of outcomes and predictors of mortality in patients with hepatopulmonary syndrome undergoing liver transplantation [J].