Repetitive transcranial magnetic stimulation of the right dorsolateral prefrontal cortex in posttraumatic stress disorder: A double-blind, placebo-controlled study

被引：202

作者：

Cohen, H ^{[1
]}

Kaplan, Z ^{[1
]}

Kotler, M ^{[1
]}

Kouperman, I ^{[1
]}

Moisa, R ^{[1
]}

Grisaru, N ^{[1
]}

机构：

[1] Ben Gurion Univ Negev, Fac Hlth Sci, Minist Hlth Mental Hlth Ctr, Anxiety & Stress Res Unit, IL-84170 Beer Sheva, Israel

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2004年 / 161卷 / 03期

关键词：

D O I：

10.1176/appi.ajp.161.3.515

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: The efficacy of repetitive transcranial magnetic stimulation (rTMS) of the right prefrontal cortex was studied in patients with posttraurnatic stress disorder (PTSD) under double-blind, placebo-controlled conditions. Method: Twenty-four patients with PTSD were randomly assigned to receive rTMS at low frequency (1 Hz) or high frequency (10 Hz) or sham rTMS in a double-blind design. Treatment was administered in 10 daily sessions over 2 weeks. Severity of PTSD, depression, and anxiety were blindly assessed before, during, and after completion of the treatment protocol. Results: The 10 daily treatments of 10-Hz rTMS at 80% motor threshold over the right dorsolateral prefrontal cortex had therapeutic effects on PTSD patients. PTSD core symptoms (reexperiencing, avoidance) markedly improved with this treatment. Moreover, high-frequency rTMS over the right dorsolateral prefrontal cortex alleviated anxiety symptoms in PTSD patients. Conclusions: This double-blind, controlled trial suggests that in PTSD patients, 10 daily sessions of right dorsolateral prefrontal rTMS at a frequency of 10 Hz have greater therapeutic effects than slow-frequency or sham stimulation.

引用

页码：515 / 524

页数：10

共 76 条

[1] Right prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder:: A double-blind, placebo-controlled study [J].