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Chromosomal localisation of genes coding for human and mouse liver cytosolic cysteine dioxygenase

被引：9
作者：
Jeremiah, S
McCann, KP
Williams, AC
Ramsden, DB
Pilz, AJ
Fox, MF
Povey, S
机构：
[1] UNIV BIRMINGHAM, QUEEN ELIZABETH HOSP, DEPT CLIN NEUROL, BIRMINGHAM B15 2TH, W MIDLANDS, ENGLAND
[2] UNIV BIRMINGHAM, QUEEN ELIZABETH HOSP, DEPT MED, BIRMINGHAM B15 2TH, W MIDLANDS, ENGLAND
[3] UCL, DEPT GENET & BIOMETRY, LONDON, ENGLAND
来源：
ANNALS OF HUMAN GENETICS | 1996年 / 60卷
关键词：
D O I：
10.1111/j.1469-1809.1996.tb01169.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A panel of 22 hybrids mas tested for the presence of the gene coding for human cysteine dioxygenase (CDO) by using human specific oligonucleotide primers in the polymerase chain reaction. Detection of human CDO completely correlated with the presence of human chromosome 5. ii human total genome cosmid library was screened with a PCR product from the coding region of human CDO cDNA and the two positive clones identified were used in fluorescent in situ hybridisation (FISH) analysis on metaphase chromosome spreads. Fluorescent signals were seen on chromosome 5q22-23. Interspecific backcross mapping in the mouse indicated that Cdo, the mouse homologue of CDO, is situated in the central region of mouse chromosome 18 which shares a region of homology with human chromosome 5.
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页码：29 / 33
页数：5
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