Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor α

被引:124
作者
Franchimont, D
Galon, J
Vacchio, MS
Fan, S
Visconti, R
Frucht, DM
Geenen, V
Chrousos, GP
Ashwell, JD
O'Shea, JJ
机构
[1] NIAMSD, Lymphocyte Cell Biol Sect, Bethesda, MD 20892 USA
[2] NCI, Lab Immune Cell Biol, Bethesda, MD 20892 USA
[3] NICHHD, Pediat Endocrinol Branch, Bethesda, MD 20892 USA
[4] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.4049/jimmunol.168.5.2212
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Despite the effects of glucocorticoids on immune function, relatively little is known about glucocorticoid-inducible genes and how their products may regulate lymphocyte function. Using DNA microarray technology to analyze gene expression in PBMC from healthy donors, we identified IL-7Ralpha as a glucocorticoid-inducible gene. This observation was confirmed at the mRNA and protein levels. Conversely, TCR signaling decreased IL-7Ralpha expression, and the relative strength of signaling between these two receptors determined the final IL-7Ra levels. The up-regulation of IL-7Ralpha by glucocorticoids was associated with enhanced IL-7-mediated signaling and function. Moreover, IL-7-mediated inhibition of apoptosis at increasing concentrations of glucocorticoids is consistent with enhanced cell sensitivity to IL-7 following glucocorticoid exposure. These observations provide a mechanism by which glucocorticoids may have a positive influence on T cell survival and function.
引用
收藏
页码:2212 / 2218
页数:7
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