Rationale and design of the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) Registry

被引：145

作者：

Min, James K. ^{[1
,2
]}

Dunning, Allison ^{[3
,4
]}

Lin, Fay Y. ^{[1
]}

Achenbach, Stephan ^{[5
]}

Al-Mallah, Mouaz H. ^{[6
]}

Berman, Daniel S. ^{[7
]}

Budoff, Matthew J. ^{[8
]}

Cademartiri, Filippo ^{[9
]}

Callister, Tracy Q. ^{[10
]}

Chang, Hyuk-Jae ^{[11
]}

Cheng, Victor ^{[7
]}

Chinnaiyan, Kavitha M. ^{[12
]}

Chow, Benjamin ^{[13
]}

Delago, Augustin ^{[14
]}

Hadamitzky, Martin ^{[15
]}

Hausleiter, Jorg ^{[15
]}

Karlsberg, Ronald P. ^{[16
]}

Kaufmann, Philipp ^{[17
]}

Maffei, Erica ^{[9
]}

Nasir, Khurram ^{[18
]}

Pencina, Michael J. ^{[19
]}

Raff, Gilbert L. ^{[12
]}

Shaw, Leslee J. ^{[20
]}

Villines, Todd C. ^{[21
]}

机构：

[1] Weill Cornell Med Coll, Dept Med, New York, NY 10021 USA

[2] Weill Cornell Med Coll, Dept Radiol, New York, NY 10021 USA

[3] Weill Cornell Med Coll, Dept Publ Hlth, New York, NY 10021 USA

[4] New York Presbyterian Hosp, New York, NY 10021 USA

[5] Univ Ehrlangen, Dept Med, Ehrlangen, Germany

[6] Wayne State Univ, Dept Med, Henry Ford Hosp, Detroit, MI 48202 USA

[7] Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA

[8] Harbor UCLA Med Ctr, Dept Med, Los Angeles, CA USA

[9] Univ Hosp Parma, Dept Radiol, Parma, Italy

[10] Tennessee Heart & Vasc Inst, Hendersonville, TN USA

[11] Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea

[12] William Beaumont Hosp, Dept Cardiol, Royal Oak, MI 48072 USA

[13] Univ Ottawa, Dept Med & Radiol, Ottawa, ON K1N 6N5, Canada

[14] Capital Cardiol Associates, Albany, NY USA

[15] Univ Munich, Div Cardiol, Munich, Germany

[16] Univ Calif Los Angeles, David Geffen Sch Med, Cardiovasc Res Fdn, Beverly Hills, CA USA

[17] Univ Zurich Hosp, CH-8091 Zurich, Switzerland

[18] Yale Univ, Sch Med, New Haven, CT USA

[19] Harvard Clin Res Inst, Boston, MA USA

[20] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA

[21] Walter Reed Army Med Ctr, Dept Internal Med, Serv Cardiol, Washington, DC 20307 USA

来源：

JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY | 2011年 / 5卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

Computed tomography; Atherosclerosis; Prognosis; Coronary disease; Nonobstructive;

D O I：

10.1016/j.jcct.2011.01.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Coronary computed tomographic angiography (CCTA) of 64-detector rows or greater represents a novel noninvasive anatomic method for evaluation of patients with suspected coronary artery disease (CAD). Early studies suggest a potential for prognostic risk assessment by CCTA findings but were limited by small patient cohorts or single centers. The CONFIRM (COronary CTAngiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry is a large, prospective, multinational dynamic observational study of patients undergoing CCTA. The primary aim of CONFIRM is to determine the prognostic value of CCTA findings for the prediction of future adverse CAD events. METHODS: The CONFIRM registry currently represents 27,125 consecutive patients at 12 cluster sites in 6 countries in North America, Europe, and Asia. CONFIRM sites were chosen on the basis of adequate CCTA volume, site CCTA proficiency, and local demographic characteristics and medical facilities to ensure a broad-based sample of patients. Patients comprising the present CONFIRM cohort include those with suspected but without known CAD, with known CAD, or asymptomatic persons undergoing CAD evaluation. A data dictionary comprising a wide array of demographic, clinical, and CCTA findings was developed by the CONFIRM investigators and is uniformly used for all patients. Patients are followed up after CCTA performance to identify adverse CAD events, including death, myocardial infarction, unstable angina, target vessel revascularization, and CAD-related hospitalization. CONCLUSIONS: From a number of countries worldwide, the information collected from the CONFIRM registry will add incremental and important insights into CCTA findings that confer prognostic value beyond demographic and clinical characteristics. The results of the CONFIRM registry will provide valuable information about the optimal methods for using CCTA findings. (C) 2011 Society of Cardiovascular Computed Tomography. All rights reserved.

引用

页码：84 / 92

页数：9

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