Carbonic anhydrase gating of attention: memory therapy and enhancement

被引：182

作者：

Sun, MK ^{[1
]}

Alkon, DL ^{[1
]}

机构：

[1] W Virginia Univ, Blanchette Rockefeller Neurosci Inst, Rockville, MD 20850 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 02期

关键词：

D O I：

10.1016/S0165-6147(02)01899-0

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Enhancement of memory acquisition and recall represents an important pharmacological goal in the treatment of cognitive disorders. In addition to its involvement in pH regulation, HCO3- reabsorption and CO2 expiration, carbonic anhydrase plays a crucial role in signal processing, long-term synaptic transformation and attentional gating of memory storage. Carbonic anhydrase dysfunction impairs cognition and is associated with mental retardation, Alzheimer's disease and aging. The pharmacological profile of carbonic anhydrase has been refined and specific activators have been developed. In this article, an integrated view of the involvement of carbonic anhydrase activity in synaptic plasticity and cognition will be presented, with particular focus on attentional gating of spatial learning and memory.

引用

页码：83 / 89

页数：7

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