Gastric antisecretory and antiulcer activities of an ethanolic extract of Bidens pilosa L. var. radiata Schult. Bip.

被引：62

作者：

Alvarez, A

Pomar, F

Sevilla, MA

Montero, MJ

机构：

[1] Univ Salamanca, Fac Farm, Dept Fisiol & Farmacol, Lab Farmacognosia & Farmacodinamia, Salamanca 37007, Spain

[2] Inst Gastroenterol, Dept Invest, Habana 10400, Cuba

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1999年 / 67卷 / 03期

关键词：

Bidens pilosa L; Compositae; cytoprotection; antiulcer; antiacid;

D O I：

10.1016/S0378-8741(99)00092-6

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bidens pilosa var. radiata Schult. Bip. is used in folk medicine to treat stomach disorders including peptic ulcers. The ethanolic extract (0.5-2 g/kg) decreased the gastric juice volume, acid secretion, as well as pepsin secretion in pylorus ligated rats. B. pilosa extract showed antiulcer activity against indomethacin-induced gastric lesions. The extract effectively inhibited gastric haemorragic lesions induced by ethanol, and with an effective dose of 2 g/kg being more potent than sucralfate (400 mg/kg). In contrast, ranitidine (50 mg/kg) failed to reduce these lesions. These results indicate that B. pilosa ethanolic extract exerts a cytoprotective effect in addition to its gastric antisecretory activity that could be due, partly at least, to the presence of flavonoids of which quercetin was identified by HPLC. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：333 / 340

页数：8

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