Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus

被引：165

作者：

Cui, Lunbiao ^{[1
]}

Liu, Di ^{[2
,3
]}

Shi, Weifeng ^{[4
,5
]}

Pan, Jingcao ^{[6
]}

Qi, Xian ^{[1
]}

Li, Xianbin ^{[7
,8
]}

Guo, Xiling ^{[1
]}

Zhou, Minghao ^{[1
]}

Li, Wei ^{[3
]}

Li, Jun ^{[6
]}

Haywood, Joel ^{[2
]}

Xiao, Haixia ^{[9
]}

Yu, Xinfen ^{[6
]}

Pu, Xiaoying ^{[6
]}

Wu, Ying ^{[2
]}

Yu, Huiyan ^{[1
]}

Zhao, Kangchen ^{[1
]}

Zhu, Yefei ^{[1
]}

Wu, Bin ^{[1
]}

Jin, Tao ^{[10
]}

Shi, Zhiyang ^{[1
]}

Tang, Fenyang ^{[1
]}

Zhu, Fengcai ^{[1
]}

Sun, Qinglan ^{[3
]}

Wu, Linhuan ^{[3
]}

Yang, Ruifu ^{[11
]}

Yan, Jinghua ^{[2
]}

Lei, Fumin ^{[5
]}

Zhu, Baoli ^{[2
]}

Liu, Wenjun ^{[2
]}

Ma, Juncai ^{[3
]}

Wang, Hua ^{[1
]}

Gao, George F. ^{[2
,8
,12
,13
]}

机构：

[1] Jiangsu Prov Ctr Dis Control & Prevent, Minist Hlth, Key Lab Enter Pathogen Microbiol, Nanjing, Jiangsu, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China

[3] Chinese Acad Sci, Inst Microbiol, Network Informat Ctr, Beijing, Peoples R China

[4] Taishan Med Coll, Sch Basic Med Sci, Tai An, Shandong, Peoples R China

[5] Chinese Acad Sci, Inst Zool, CAS Key Lab Zool Systemat & Evolut, Beijing, Peoples R China

[6] Hangzhou Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China

[7] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Guangdong, Peoples R China

[8] Univ Chinese Acad Sci, Beijing, Peoples R China

[9] Chinese Acad Sci, Tianjin Inst Biotechnol, Tianjin, Peoples R China

[10] BGI Shenzhen, Shenzhen, Guangdong, Peoples R China

[11] Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China

[12] Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China

[13] Chinese Ctr Dis Control & Prevent China CDC, Off Director Gen, Beijing, Peoples R China

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

中国国家自然科学基金;

关键词：

ORIGIN; DIVERSITY; SELECTION; EVOLUTION; MARKETS; CHINA;

D O I：

10.1038/ncomms4142

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Influenza A (H7N9) virus has been causing human infections in China since February 2013, raising serious concerns of potential pandemics. Previous studies demonstrate that human infection is directly linked to live animal markets, and that the internal genes of the virus are derived from H9N2 viruses circulating in the Yangtze River Delta area in Eastern China. Here following analysis of 109 viruses, we show a much higher genetic heterogeneity of the H7N9 viruses than previously reported, with a total of 27 newly designated genotypes. Phylogenetic and genealogical inferences reveal that genotypes G0 and G2.6 dominantly co-circulate within poultry, with most human isolates belonging to the genotype G0. G0 viruses are also responsible for the inter-and intra-province transmissions, leading to the genesis of novel genotypes. These observations suggest the province-specific H9N2 virus gene pools increase the genetic diversity of H7N9 via dynamic reassortments and also imply that G0 has not gained overwhelming fitness and the virus continues to undergo reassortment.

引用

页数：9

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