Acidic heteroxylans from medicinal plants and their anti-ulcer activity

被引：47

作者：

Cipriani, Thales R. ^{[1
]}

Mellinger, Caroline G. ^{[1
]}

de Souza, Lauro M. ^{[1
]}

Baggio, Cristiane H. ^{[2
]}

Freitas, Cristina S. ^{[2
]}

Marques, Maria C. A. ^{[2
]}

Gorin, Philip A. J. ^{[1
]}

Sassaki, Guilherme L. ^{[1
]}

Iacomini, Marcello ^{[1
]}

机构：

[1] Univ Fed Parana, Dept Bioquim & Biol Mol, BR-81531980 Curitiba, Parana, Brazil

[2] Univ Fed Parana, Dept Farmacol, BR-81531980 Curitiba, Parana, Brazil

来源：

CARBOHYDRATE POLYMERS | 2008年 / 74卷 / 02期

关键词：

Maytenus ilicifolia; Phyllanthus niruri; polysaccharide; acidic heteroxylan; anti-ulcer activity;

D O I：

10.1016/j.carbpol.2008.02.012

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

Xylans are the main hemicelluloses found in higher plants, and are often present in phytotherapic medicines. An acidic heteroxylan was obtained from Maytenus ilicifolia leaves by hot 10% aqueous KOH extraction. This was subjected to freeze-thawing process, giving insoluble and soluble fractions and the latter treated with Fehling solution. Its insoluble fraction (MI-HX) was further examined. The acidic heteroxylan gave xylose, galactose, glucose, and 4-O-methylglucuronic acid in a 76:6:9:9 molar ratio and methylation analyses and C-13 NMR spectroscopy showed its main chain consists of 4-0-linked beta-D-Xylp units. This polysaccharide and another acidic heteroxylan from Phyllanthus niruri had anti-ulcer activity and were able to reduce gastric lesions induced by ethanol by 65% and 78%, with ED50 = 40.0 and 20.4 mg/kg, each respectively. These results suggest that this class of polysaccharide has a protective anti-ulcer effect, and that there is a relation between its chemical structure and biological function. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：274 / 278

页数：5

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