Mucosal cytokine network in inflammatory bowel disease

被引:102
作者
Andoh, Akira [1 ]
Yagi, Yuhki [1 ]
Shioya, Makoto [1 ]
Nishida, Atsushi [1 ]
Tsujikawa, Tomoyuki [1 ]
Fujiyama, Yoshihide [1 ]
机构
[1] Shiga Univ Med Sci, Dept Med, Otsu, Shiga 5202192, Japan
关键词
cytokine; inflammatory bowel disease; interleukin-17; interleukin-31; interleukin-32;
D O I
10.3748/wjg.14.5154
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are characterized by ongoing mucosal inflammation in which dysfunction of the host immunologic response against dietary factors and commensal bacteria is involved. The chronic inflammatory process leads to disruption of the epithelial barrier, and the formation of epithelial ulceration. This permits easy access for the luminal microbiota and dietary antigens to cells resident in the lamina propria, and stimulates further pathological immune cell responses. Cytokines are essential mediators of the interactions between activated immune cells and non-immune cells, including epithelial and mesenchymal cells. The clinical efficacy of targeting TNF-alpha clearly indicates that cytokines are the therapeutic targets in IBD patients. In this manuscript, we focus on the biological activities of recently-reported cytokines [Interleukin (IL)-17 cytokine family, IL-31 and IL-32], which might play a role through interaction with TNF-alpha in the pathophysiology of IBD.
引用
收藏
页码:5154 / 5161
页数:8
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