Human myeloma cells express the CD38 ligand CD31

被引：28

作者：

Vallario, A

Chilosi, M

Adami, F

Montagna, L

Deaglio, S

Malavasi, F

Caligaris-Cappio, F

机构：

[1] Univ Turin, Osped Mauriziano Umberto 1, Dipartimento Sci Biomed & Oncol Umana, I-10128 Turin, Italy

[2] Ist Ric & Cura Canc, Candiolo, Italy

[3] Univ Verona, Ist Anat Patol, I-37100 Verona, Italy

[4] Univ Padua, Dipartimento Med Clin & Sperimentale, I-35100 Padua, Italy

[5] Univ Turin, Dipartimento Genet Biol & Chim Med, Turin, Italy

[6] Univ Ancona, Ist Biol & Genet, Ancona, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1999年 / 105卷 / 02期

关键词：

multiple myeloma; plasma cells; CD38; CD31; receptors;

D O I：

10.1111/j.1365-2141.1999.01321.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple myeloma (MM) plasma cells (PC) are CD38(+). A ligand for CD38 is the adhesion molecule CD31, By flow cytometry and immunocytochemistry we have investigated whether malignant PC co-express CD38 and CD31. All 68 patients studied were CD38(+). 14/14 monoclonal gammopathies of undetermined significance (MGUS) and 39/39 plasmacytic MM patients co-expressed CD38 and CD31 at high density, Only 1/11 plasmablastic MM and 1/4 plasma cell leukaemias (PCL) expressed CD31. These data indicated that PC malignancies co-expressed high levels of both CD38 and its ligand CD31, with the exception of plasmablastic MM and PCL.

引用

页码：441 / 444

页数：4

共 13 条

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