Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

被引：2326

作者：

Vrieze, Anne ^{[1
]}

Van Nood, Els ^{[1
]}

Holleman, Frits ^{[1
]}

Salojarvi, Jarkko ^{[6
]}

Kootte, Ruud S. ^{[2
]}

Bartelsman, Joep F. W. M. ^{[3
]}

Dallinga-Thie, Geesje M. ^{[2
]}

Ackermans, Mariette T. ^{[4
]}

Serlie, Mireille J. ^{[5
]}

Oozeer, Raish ^{[7
]}

Derrien, Muriel ^{[7
]}

Druesne, Anne ^{[7
]}

Vlieg, Johan E. T. Van Hylckama ^{[7
]}

Bloks, Vincent W. ^{[8
]}

Groen, Albert K. ^{[8
]}

Heilig, Hans G. H. J. ^{[9
]}

Zoetendal, Erwin G. ^{[9
]}

Stroes, Erik S. ^{[2
]}

de Vos, Willem M. ^{[6
,9
]}

Hoekstra, Joost B. L. ^{[1
]}

Nieuwdorp, Max ^{[1
,2
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med & Expt Vasc Med, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Clin Chem, Lab Endocrinol, NL-1105 AZ Amsterdam, Netherlands

[5] Univ Amsterdam, Acad Med Ctr, Dept Endocrinol & Metab, NL-1105 AZ Amsterdam, Netherlands

[6] Univ Helsinki, Dept Basic Vet Med, Helsinki, Finland

[7] Danone Res, Ctr Daniel Carasso, Palaiseau, France

[8] Univ Groningen, Univ Med Ctr Groningen, Ctr Liver Digest & Metab Dis, Groningen, Netherlands

[9] Wageningen Univ, Microbiol Lab, Wageningen, Netherlands

来源：

GASTROENTEROLOGY | 2012年 / 143卷 / 04期

关键词：

Bacteria; Clinical Trial; Diabetes; Short-Chain Fatty Acids; GUT MICROBIOTA; OBESITY; BUTYRATE; BACTERIA; PROBE;

D O I：

10.1053/j.gastro.2012.06.031

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 mu mol/kg/min; P < .05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776).

引用

页码：913 / +

页数：11

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