Biological roles of lysophospholipid receptors revealed by genetic null mice: An update

被引：107

作者：

Choi, Ji Woong ^{[1
]}

Lee, Chang-Wook ^{[1
]}

Chun, Jerold ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol Biol, Helen L Dorris Child & Adolescent Neuropsychiat D, La Jolla, CA 92037 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2008年 / 1781卷 / 09期

基金：

美国国家卫生研究院;

关键词：

LPA; S1P; sphingosine; lysophosphatidic acid; phospholipid; lysophospholipid;

D O I：

10.1016/j.bbalip.2008.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two lysophospholipids (LPs), lysophosphaticlic acid (LPA) and sphingosine 1-phosphate (S1P), are known to affect various cellular events. Their actions are mediated by binding to at least ten bona fide high-affinity G protein-coupled receptors referred to as LPA(1-5) and S1P(1-s). These LPs are expressed throughout the body and are involved in a range of biological activities including normal development, as well as functioning in most organ systems. A growing number of biological functions have been uncovered in vivo using single- or multiple-null mice for each LP receptor. This review will focus On findings from in vivo as well as in vitro studies using genetic null mice for the LP receptors, LPA(1,2,3) and S1P(1,2,3,5). and for the LP producing enzymes, autotaxin and sphingosine kinase 1/2. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：531 / 539

页数：9

共 121 条

[1] Regulation and functional roles of sphingosine kinases [J].

Alemany, Regina ;

van Koppen, Chris J. ;

Danneberg, Kerstin ;

ter Braak, Michael ;

Heringdorf, Dagmar Meyer zu .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2007, 374 (5-6) :413-428

[2] Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720 [J].

Allende, ML ;

Sasaki, T ;

Kawai, H ;

Olivera, A ;

Mi, YD ;

van Echten-Deckert, G ;

Hajdu, R ;

Rosenbach, M ;

Keohane, CA ;

Mandala, S ;

Spiegel, S ;

Proia, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (50) :52487-52492

[3] Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration [J].

Allende, ML ;

Dreier, JL ;

Mandala, S ;

Proia, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) :15396-15401

[4] G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation [J].

Allende, ML ;

Yamashita, T ;

Proia, RL .

BLOOD, 2003, 102 (10) :3665-3667

[5] Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid [J].

An, SZ ;

Bleu, T ;

Hallmark, OG ;

Goetzl, EJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (14) :7906-7910

[6] Cell surface receptors in lysophospholipid signaling [J].

Anliker, B ;

Chun, J .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2004, 15 (05) :457-465

[7] Lysophospholipid G protein-coupled receptors [J].

Anliker, B ;

Chun, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (20) :20555-20558

[8] Mechanisms of lysophosphatidic acid production [J].

Aoki, J .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2004, 15 (05) :477-489

[9] Direct quantitative analysis of lysophosphatidic acid molecular species by stable isotope dilution electrospray ionization liquid chromatography-mass spectrometry [J].

Baker, DL ;

Desiderio, DM ;

Miller, DD ;

Tolley, B ;

Tigyi, GJ .

ANALYTICAL BIOCHEMISTRY, 2001, 292 (02) :287-295

[10] Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid [J].

Bandoh, K ;

Aoki, J ;

Hosono, H ;

Kobayashi, S ;

Kobayashi, T ;

Murakami-Murofushi, K ;

Tsujimoto, M ;

Arai, H ;

Inoue, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (39) :27776-27785

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