Three-dimensional microfluidic tissue-engineering scaffolds using a flexible biodegradable polymer

被引：216

作者：

Bettinger, CJ

Weinberg, EJ

Kulig, KM

Vacanti, JP

Wang, YD

Borenstein, JT

Langer, R

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] Charles Stark Draper Lab Inc, MEMS Technol Grp, Cambridge, MA 02139 USA

[3] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

[4] MIT, Dept Mech Engn, Cambridge, MA 02139 USA

[5] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Boston, MA 02114 USA

[6] Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30332 USA

来源：

ADVANCED MATERIALS | 2006年 / 18卷 / 02期

关键词：

D O I：

10.1002/adma.200500438

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three-dimensional microfluidic networks using a flexible biodegradable polymer have been fabricated using modified microfabrication processes tailored specifically for poly(glycerol-co-sebacate). A model hepatocyte cell line (HepG(2)) is seeded and pet-fused in the microfluidic networks to demonstrate cell viability and function, which is maintained in long-term perfusion culture (see Figure; scale bar is 50 mu m). The seeded, fully degradable device can potentially be integrated into a patient's existing vasculature in order to restore organ function.

引用

页码：165 / +

页数：6

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