Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines

被引：494

作者：

Murakami, Masaaki ^{[1
,2
]}

Kamimura, Daisuke ^{[1
,2
]}

Hirano, Toshio ^{[1
,2
,3
]}

机构：

[1] Hokkaido Univ, Inst Genet Med, Div Mol Psychoimmunol, Sapporo, Hokkaido 0600815, Japan

[2] Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido 0600815, Japan

[3] Natl Inst Quantum & Radiol Sci & Technol, Chiba 2638555, Japan

来源：

IMMUNITY | 2019年 / 50卷 / 04期

关键词：

LEUKEMIA INHIBITORY FACTOR; CILIARY NEUROTROPHIC FACTOR; HEPATOCYTE-STIMULATING FACTOR; INDUCED SWEATING SYNDROME; IL-6 SIGNAL TRANSDUCER; ONCOSTATIN-M RECEPTOR; RECOMBINANT HUMAN INTERLEUKIN-11; CARDIOTROPHIN-LIKE CYTOKINE; MESSENGER-RNA STABILITY; GENOME-WIDE ASSOCIATION;

D O I：

10.1016/j.immuni.2019.03.027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

since the molecular dolling of interleukin-6 (IL-6) in 1986, many other cytokines have been found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL-6 family of cytokines now consists of ten members. Although some of the family members' functions are redundant as a result of the expression of gp130, there are also functional distinctions between members. The mechanisms that determine functional redundancies and distinctions are not completely understood. Yet, research has clarified the role of IL-6 family cytokines in autoimmune diseases and has led to effective therapies that target them. Here, we review the IL-6 family of cytokines in autoimmune diseases, with a particular focus on the prototypical member IL-6, from the viewpoints of their structure, signaling, and biological features and discuss possible mechanisms of their functional pleiotropy.

引用

页码：812 / 831

页数：20

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