Hepatoprotective effect of the flavonoid fraction isolated from the flower of Inula britannica against D-Galactosamine-induced hepatic injury

被引：35

作者：

Dong, Man ^{[1
]}

Hong, Tie ^{[1
]}

Liu, Shunan ^{[1
]}

Zhao, Jing ^{[1
]}

Meng, Yixiao ^{[2
]}

Mu, Jiaye ^{[2
]}

机构：

[1] Jilin Univ, Sch Pharm, Dept Pharmacol, Changchun 130021, Jilin, Peoples R China

[2] Yanbian Univ, Hlth Sci Ctr, Yanji 133002, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2013年 / 7卷 / 06期

关键词：

Inula britannica flower flavonoids; D-Galactosamine; oxidative stress; inflammatory response; mouse liver injury; OXIDATIVE STRESS; INFLAMMATORY RESPONSE; NITRIC-OXIDE; MOUSE-LIVER; MICE;

D O I：

10.3892/mmr.2013.1443

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The aim of this study was to investigate the mechanism and nature of the protective effect of Inula britannica flower flavonoids (IBFF) on antioxidants and the inhibition of inflammation in liver injury. Liver injury was induced in a mouse model by intraperitoneal injection of D-Galactosamine (D-Gal; 850 mg/kg) and IBFF was administered orally at 125, 250 or 500 mg/kg once a day for 7 days. The results revealed that IBFF reversed the increases in serum aminotransferase levels and lipid peroxidation and also reversed the decreases in hepatic glutathione content. IBFF attenuated the D-Gal-induced increases in tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA and protein levels in the liver. Our data suggest that IBFF ameliorates D-Gal-induced acute liver injury and that this protection may be due to its antioxidative and anti-inflammatory activities.

引用

页码：1919 / 1923

页数：5

共 20 条

[1]

Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines [J].