HIV-associated sensory neuropathy: still a problem in the post-stavudine era?

被引：9

作者：

Cherry, Catherine L. ^{[1
,2
,3
]}

Kamerman, Peter R. ^{[3
]}

Bennett, David L. H. ^{[4
]}

Rice, Andrew S. C. ^{[5
,6
,7
]}

机构：

[1] Monash Univ, Alfred Hosp, Ctr Virol, Infect Dis Unit,Burnet Inst, Clayton, Vic 3800, Australia

[2] Monash Univ, Fac Med Nursing & Hlth Sci, Clayton, Vic 3800, Australia

[3] Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, Brain Funct Res Grp, ZA-2050 Johannesburg, South Africa

[4] Kings Coll London, Neurorestorat Grp, CARD Wolfson, London, England

[5] Univ London Imperial Coll Sci Technol & Med, Pain Res Grp, London SW7 2AZ, England

[6] Chelsea & Westminster Hosp, Dept Pain Med, London, England

[7] Chelsea & Westminster Hosp, Dept Surg & Canc, London, England

来源：

FUTURE VIROLOGY | 2012年 / 7卷 / 09期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

HIV; neuropathogenesis; pain; sensory neuropathy; stavudine; COMBINATION ANTIRETROVIRAL THERAPY; PERIPHERAL NEUROPATHY; IMMUNODEFICIENCY SYNDROME; INFECTED PATIENTS; LIFE EXPECTANCY; RODENT MODELS; RABBIT MODEL; TENOFOVIR DF; DOUBLE-BLIND; RISK-FACTORS;

D O I：

10.2217/FVL.12.77

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Sensory neuropathy (SN) is a common and difficult to manage cause of chronic pain in HIV. Recent recommendations for earlier HIV treatment and avoidance of neurotoxic antiretroviral drugs (such as stavudine) have led to optimism that HIV-SN rates may decline. We present several reasons as to why HIV-SN is likely to remain prevalent, despite improvements in HIV management, together with clinical evidence confirming high HIV-SN rates in cohorts never exposed to neurotoxic medications. A combination of epidemiologic studies, laboratory work and clinical trials are needed to understand the problem of HIV-SN in the post-stavudine era. Improved HIV-SN prevention and management strategies are needed if the morbidity associated with HIV infection is to improve along with life expectancy.

引用

页码：849 / 854

页数：6

共 63 条

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Can We Predict Neuropathy Risk before Stavudine Prescription in a Resource-Limited Setting? [J].