Interaction of 9,10-anthraquinone with adenine and 2′-deoxyadenosine

被引：10

作者：

Bose, Adity ^{[1
]}

Sarkar, Achintya K. ^{[2
]}

Basu, Samita ^{[1
]}

机构：

[1] Saha Inst Nucl Phys, Div Chem Sci, Kolkata 700064, India

[2] Presidency Coll, Dept Chem, Kolkata 700073, India

来源：

BIOPHYSICAL CHEMISTRY | 2008年 / 136卷 / 01期

关键词：

9,10-anthraquinone; adenine; 2 '-deoxyadenosine; magnetic field effect; hydrogen bonding; aromaticity;

D O I：

10.1016/j.bpc.2008.04.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Laser flash photolysis has been used for the study of the interaction of 9,10-anthraquinone (AQ) with the DNA base, adenine (A) and its corresponding nucleoside, 2'-deoxyadenosine (dA). This study has provided two very important observations. AQ has been found to support electron transfer in different categories of media, acetonitrile/water on one hand and SDS micelles on other. While in our earlier work 2-methyl 1,4-naphthoquinone was found to undergo a switchover in reactivity a. Am. Chem. Soc. 126 (2004) 1058910593). Again A and dA are found to behave differently on account of an extra sugar unit, which not only affects the rate of reaction but the reaction pathway has been found to be modified too. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：59 / 65

页数：7

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